Sugi Predict

Sugi Predict / Compounds / SCHEMBL19690293

SCHEMBL19690293

SCHEMBL19690293

Nc1cc(N2Cc3ccc(C(F)(F)F)cc3C2)ccc1[N+](=O)[O-]

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 6/20 0.54
▸ MAPT P10636 9/20 0.54
▸ SIRT6 Q8N6T7 2/20 0.54
▸ RECQL P46063 1/20 0.51
▸ HTT P42858 2/20 0.47
▸ ALDH1A1 P00352 4/20 0.44
▸ MEN1 O00255 2/20 0.41
▸ KMT2A Q03164 2/20 0.41
▸ CYP1A2 P05177 2/20 0.41
▸ CYP2C19 P33261 2/20 0.41
▸ CYP3A4 P08684 1/20 0.41
▸ CYP2D6 P10635 1/20 0.41
▸ CYP2C9 P11712 1/20 0.41
▸ L3MBTL1 Q9Y468 2/20 0.40
▸ TSHR P16473 1/20 0.40
▸ TDP1 Q9NUW8 1/20 0.40
▸ KDM4E B2RXH2 1/20 0.39
▸ MAPK1 P28482 1/20 0.39
▸ RAB9A P51151 1/20 0.39
▸ SMN1; SMN2 Q16637 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19690352 0.92 MAPT (0.55) LMNAMAPTSIRT6RECQLHTT
SCHEMBL19690360 0.92 MAPT (0.55) LMNAMAPTSIRT6RECQLHTT
SCHEMBL19690443 0.84 LMNA (0.58) LMNAMAPTSIRT6RECQLHTT
SCHEMBL19690305 0.79 MAPT (0.45) LMNAMAPTSIRT6RECQLHTT
SCHEMBL331522 0.78 ALDH1A1 (0.64) LMNAMAPTALDH1A1MEN1KMT2A
SCHEMBL19690301 0.76 LMNA (0.58) LMNAMAPTSIRT6RECQLHTT
SCHEMBL19690292 0.76 LMNA (0.58) LMNAMAPTSIRT6RECQLHTT
SCHEMBL19690295 0.74 ALDH1A1 (0.42) MAPTHTTALDH1A1MEN1KMT2A
SCHEMBL19690307 0.73 LMNA (0.46) LMNAMAPTRECQLHTTALDH1A1
SCHEMBL19690477 0.73 LMNA (0.46) LMNAMAPTRECQLHTTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11858900-B2 Fluorinated 2-amino-4-(substituted amino)phenyl carbamate derivatives OCUTERRA THERAPEUTICS, INC. (US) 2024-01-02 — — US disclosed
US-20210309612-A1 FLUORINATED 2-AMINO-4-(SUBSTITUTED AMINO)PHENYL CARBAMATE DERIVATIVES OCUTERRA THERAPEUTICS, INC. 2021-10-07 — — US disclosed
EP-3468947-A1 FLUORINATED 2-AMINO-4-(SUBSTITUTED AMINO)PHENYL CARBAMATE DERIVATIVES SciFluor Life Sciences, Inc. (US) 2019-04-17 — — EP disclosed
WO-2017214539-A1 FLUORINATED 2-AMINO-4-(SUBSTITUTED AMINO)PHENYL CARBAMATE DERIVATIVES SCIFLUOR LIFE SCIENCES, INC. (US) 2017-12-14 — — WO disclosed
US-20170355679-A1 FLUORINATED 2-AMINO-4-(SUBSTITUTED AMINO)PHENYL CARBAMATE DERIVATIVES SCIFLUOR LIFE SCIENCES, INC. 2017-12-14 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170355679-A1 FLUORINATED 2-AMINO-4-(SUBSTITUTED AMINO)PHENYL CARBAMATE DERIVATIVES KCNQ2, KCNQ1, KCNQ3 LMNA 2343/4885MAPT 2123/4885SIRT6 1361/4885
US-11858900-B2 Fluorinated 2-amino-4-(substituted amino)phenyl carbamate derivatives KCNQ2, KCNQ1, KCNQ3 LMNA 2343/4885MAPT 2123/4885SIRT6 1361/4885
US-20210309612-A1 FLUORINATED 2-AMINO-4-(SUBSTITUTED AMINO)PHENYL CARBAMATE DERIVATIVES KCNQ2, KCNQ1, KCNQ3 LMNA 2343/4885MAPT 2123/4885SIRT6 1361/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.