Sugi Predict

Sugi Predict / Compounds / SCHEMBL19690397

SCHEMBL19690397

SCHEMBL19690397

O=C(O)C(C1c2ccccc2-c2ccccc21)C(C(=O)O)C1c2ccccc2-c2ccccc21

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CYP1A2 P05177 1/20 0.59
▸ TSHR P16473 1/20 0.59
▸ HDAC3 O15379 1/20 0.44
▸ HDAC4 P56524 1/20 0.44
▸ HDAC7 Q8WUI4 1/20 0.44
▸ HDAC8 Q9BY41 1/20 0.44
▸ HDAC6 Q9UBN7 1/20 0.44
▸ HDAC9 Q9UKV0 1/20 0.44
▸ HDAC5 Q9UQL6 1/20 0.44
▸ NCOR2 Q9Y618 1/20 0.44
▸ POLB P06746 1/20 0.42
▸ EDNRB P24530 1/20 0.41
▸ EDNRA P25101 1/20 0.41
▸ MAPT P10636 2/20 0.41
▸ KMT2A Q03164 2/20 0.39
▸ CYP2D6 P10635 1/20 0.38
▸ SRC P12931 1/20 0.38
▸ ALDH1A1 P00352 2/20 0.37
▸ L3MBTL1 Q9Y468 1/20 0.37
▸ LMNA P02545 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28005718 0.83 TSHR (0.49) CYP1A2TSHRPOLBKMT2AALDH1A1
SCHEMBL8197048 0.79 CYP1A2 (0.56) CYP1A2TSHRHDAC3HDAC4HDAC7
SCHEMBL7681625 0.79 CYP1A2 (0.56) CYP1A2TSHRHDAC3HDAC4HDAC7
SCHEMBL21758209 0.79 CYP1A2 (0.56) CYP1A2TSHRHDAC3HDAC4HDAC7
SCHEMBL3136524 0.79 CYP1A2 (0.56) CYP1A2TSHRHDAC3HDAC4HDAC7
Hydrochloric Acid SCHEMBL9090573 0.78 CYP1A2 (0.54) CYP1A2TSHRHDAC3HDAC4HDAC7
SCHEMBL26017055 0.77 CYP1A2 (0.42) CYP1A2TSHRPOLBKMT2A
SCHEMBL5275777 0.75 CYP1A2 (1.00) CYP1A2TSHRHDAC3HDAC4HDAC7
SCHEMBL30483907 0.75 CYP1A2 (1.00) CYP1A2TSHRHDAC3HDAC4HDAC7
SCHEMBL29015983 0.74 TSHR (0.50) CYP1A2TSHRHDAC3HDAC4HDAC7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107417819-B Solid catalyst component for olefin polymerization, catalyst and application thereof 北京利和知信科技有限公司 2021-11-16 — — CN disclosed
US-11136421-B2 Solid catalyst component for use in olefin polymerisation, catalyst, and application thereof BEIJING LIHE TECHNOLOGY LTD (CN) 2021-10-05 — — US disclosed
US-20200071430-A1 SOLID CATALYST COMPONENT FOR USE IN OLEFIN POLYMERISATION, CATALYST, AND APPLICATION THEREOF BEIJING LIHE TECH LTD (CN) 2020-03-05 — — US disclosed
US-20190169328-A1 OLEFIN POLYMERIZATION CATALYST CARRIER, SOLID CATALYST COMPONENT AND USE THEREOF RENQIU LIHE TECH LTD (CN) 2019-06-06 — — US disclosed
US-20170355792-A1 OLEFIN POLYMERIZATION CATALYST CARRIER, SOLID CATALYST COMPONENT AND USE THEREOF RENQIU LIHE TECH LTD (CN) 2017-12-14 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190169328-A1 OLEFIN POLYMERIZATION CATALYST CARRIER, SOLID CATALYST COMPONENT AND USE THEREOF COG2, GTF2I, POF1B CYP1A2 175/4885TSHR 2613/4885HDAC3 4162/4885
US-20170355792-A1 OLEFIN POLYMERIZATION CATALYST CARRIER, SOLID CATALYST COMPONENT AND USE THEREOF COG2, COG7, COG4 CYP1A2 383/4885TSHR 3704/4885HDAC3 4589/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.