Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL65879 | 0.89 | TSHR (0.35) | — | |
| Tromethamine SCHEMBL9075697 | 0.85 | — | — | |
| Glycerin SCHEMBL2138419 | 0.83 | TSHR (0.30) | — | |
| SCHEMBL9418352 | 0.83 | TSHR (0.32) | — | |
| SCHEMBL5837859 | 0.81 | TSHR (0.33) | — | |
| SCHEMBL8167214 | 0.81 | TSHR (0.33) | — | |
| SCHEMBL4972445 | 0.81 | TSHR (0.33) | — | |
| SCHEMBL4884446 | 0.80 | TSHR (0.32) | — | |
| Tromethamine SCHEMBL20506918 | 0.78 | TSHR (0.30) | — | |
| SCHEMBL3448578 | 0.77 | TSHR (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9255199-B2 | Hydrophilic silicone monomers, process for their preparation and thin films containing the same | MOMENTIVE PERFORMANCE MATERIALS INC. (US) | 2016-02-09 | — | — | US | disclosed |
| EP-2334382-B1 | HYDROPHILIC SILICONE MONOMERS, PROCESS FOR THEIR PREPARATION AND THIN FILMS CONTAINING THE SAME | MOMENTIVE PERFORMANCE MAT INC (US) | 2014-07-23 | — | — | EP | disclosed |
| US-20140163135-A1 | HYDROPHILIC SILICONE MONOMERS, PROCESS FOR THEIR PREPARATION AND THIN FILMS CONTAINING THE SAME | MOMENTIVE PERFORMANCE MATERIALS INC. | 2014-06-12 | — | — | US | disclosed |
| US-20110181833-A1 | HYDROPHILIC SILICONE MONOMERS, PROCESS FOR THEIR PREPARATION AND THIN FILMS CONTAINING THE SAME | MOMENTIVE PERFORMANCE MATERIALS INC. | 2011-07-28 | — | — | US | disclosed |
| EP-2334382-A2 | HYDROPHILIC SILICONE MONOMERS, PROCESS FOR THEIR PREPARATION AND THIN FILMS CONTAINING THE SAME | Momentive Performance Materials Inc. (US) | 2011-06-22 | — | — | EP | disclosed |
| WO-2010038242-A2 | HYDROPHILIC SILICONE MONOMERS, PROCESS FOR THEIR PREPARATION AND THIN FILMS CONTAINING THE SAME | MOMENTIVE PERFORMANCE MATERIALS INC. (US) | 2010-04-08 | — | — | WO | disclosed |