Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.63 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.63 |
| ▸ | HTR2A | P28223 | 3/20 | 0.59 |
| ▸ | HTR6 | P50406 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 5/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1971767 | 0.84 | HTR2A (0.56) | MTNR1AMTNR1BHTR2AFTOADRB3 | |
| SCHEMBL1969255 | 0.81 | MPO (0.57) | MTNR1AMTNR1BHTR2AHTR6FTO | |
| SCHEMBL27085142 | 0.78 | MTNR1A (1.00) | MTNR1AMTNR1BHTR2AHTR6HTR1A | |
| SCHEMBL30630329 | 0.78 | MTNR1A (1.00) | MTNR1AMTNR1BHTR2AHTR6HTR1A | |
| SCHEMBL1965743 | 0.77 | MPO (0.60) | MTNR1AMTNR1BHTR2AGAAKMT2A | |
| SCHEMBL11301389 | 0.76 | HTR2A (0.44) | MTNR1AMTNR1BHTR2AHTR1AKMT2A | |
| SCHEMBL1968351 | 0.75 | BCHE (0.67) | MTNR1AHTR2AHTR1AKMT2ALMNA | |
| SCHEMBL1424902 | 0.74 | HTR2A (1.00) | MTNR1AMTNR1BHTR2AHTR6HTR1A | |
| SCHEMBL5947535 | 0.74 | KMT2A (0.64) | MTNR1AMTNR1BHTR2AHTR6GAA | |
| SCHEMBL1969126 | 0.74 | HTR6 (0.72) | MTNR1AMTNR1BHTR2AHTR6FTO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110212968-A1 | PHENETHYLAMIDE DERIVATIVES AND THEIR HETEROCYCLIC ANALOGUES | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-09-01 | — | — | US | disclosed |
| EP-2334643-A1 | PHENETHYLAMIDE DERIVATIVES AND THEIR HETEROCYCLIC ANALOGUES | Actelion Pharmaceuticals Ltd. (CH) | 2011-06-22 | — | — | EP | disclosed |
| WO-2010044054-A1 | PHENETHYLAMIDE DERIVATIVES AND THEIR HETEROCYCLIC ANALOGUES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-04-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110212968-A1 | PHENETHYLAMIDE DERIVATIVES AND THEIR HETEROCYCLIC ANALOGUES | HCRTR2, HCRTR1, HRH3 | MTNR1A 23/4885MTNR1B 22/4885HTR2A 46/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.