Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 15/20 | 0.64 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.64 |
| ▸ | ADAM17 | P78536 | 6/20 | 0.63 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.63 |
| ▸ | MMP12 | P39900 | 1/20 | 0.63 |
| ▸ | ADAM9 | Q13443 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17870638 | 0.87 | ADAMTS5 (0.63) | ADAMTS5ADAMTS4ADAM17ADAM10MMP12 | |
| SCHEMBL19691588 | 0.78 | ADAMTS5 (0.69) | ADAMTS5ADAMTS4ADAM17ADAM10MMP12 | |
| SCHEMBL20708541 | 0.78 | ADAMTS5 (1.00) | ADAMTS5ADAMTS4ADAM17ADAM10MMP12 | |
| SCHEMBL23745421 | 0.77 | ADAMTS5 (0.66) | ADAMTS5ADAMTS4ADAM17ADAM10MMP12 | |
| SCHEMBL20708412 | 0.77 | ADAMTS5 (0.80) | ADAMTS5ADAMTS4ADAM17ADAM10MMP12 | |
| SCHEMBL20708337 | 0.77 | ADAMTS5 (0.80) | ADAMTS5ADAMTS4ADAM17ADAM10MMP12 | |
| SCHEMBL19691635 | 0.76 | ADAM17 (0.65) | ADAMTS5ADAMTS4ADAM17ADAM10MMP12 | |
| SCHEMBL23745417 | 0.76 | ADAMTS5 (0.67) | ADAMTS5ADAMTS4ADAM17ADAM10MMP12 | |
| SCHEMBL23745408 | 0.75 | ADAMTS5 (0.58) | ADAMTS5ADAMTS4ADAM17ADAM10MMP12 | |
| SCHEMBL20708523 | 0.75 | ADAMTS5 (0.72) | ADAMTS5ADAMTS4ADAM17ADAM10MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3468961-B1 | 5-[3-[PIPERIDIN-1-YL]-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS 4 AND 5 INHIBITORS FOR TREATING E.G. OSTEOARTHRITIS | GALAPAGOS NV (BE) | 2020-06-10 | — | — | EP | disclosed |
| EP-3468961-B1 | 5-[3-[PIPERIDIN-1-YL]-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS 4 AND 5 INHIBITORS FOR TREATING E.G. OSTEOARTHRITIS | GALAPAGOS NV (BE) | 2020-06-10 | — | — | EP | disclosed |
| EP-3468961-A1 | 5-[3-[PIPERIDIN-1-YL]-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS 4 AND 5 INHIBITORS FOR TREATING E.G. OSTEOARTHRITIS | Galapagos NV (BE) | 2019-04-17 | — | — | EP | disclosed |
| EP-3468961-A1 | 5-[3-[PIPERIDIN-1-YL]-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS 4 AND 5 INHIBITORS FOR TREATING E.G. OSTEOARTHRITIS | Galapagos NV (BE) | 2019-04-17 | — | — | EP | disclosed |
| WO-2017211667-A1 | 5-[3-[PIPERIDIN-1-YL]-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS 4 AND 5 INHIBITORS FOR TREATING E.G. OSTEOARTHRITIS | GALAPAGOS NV (BE) | 2017-12-14 | — | — | WO | disclosed |
| WO-2017211667-A1 | 5-[3-[PIPERIDIN-1-YL]-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS 4 AND 5 INHIBITORS FOR TREATING E.G. OSTEOARTHRITIS | GALAPAGOS NV (BE) | 2017-12-14 | — | — | WO | disclosed |