Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 8/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.41 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.39 |
| ▸ | PDE4A | P27815 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | KDM6B | O15054 | 2/20 | 0.37 |
| ▸ | KDM5A | P29375 | 1/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2947337 | 0.86 | LTB4R (0.48) | LTB4RALDH1A1PDE4APDE4BPDE4C | |
| SCHEMBL19695908 | 0.82 | LTB4R (0.36) | ROCK2LTB4RNAMPTALDH1A1LMNA | |
| SCHEMBL15396768 | 0.79 | ROCK2 (0.45) | KDM4CROCK2NAMPTALDH1A1LMNA | |
| SCHEMBL2950213 | 0.74 | FFAR1 (0.43) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2950480 | 0.70 | LTB4R (0.61) | LTB4RALDH1A1HTTSMN1; SMN2PDE4D | |
| SCHEMBL9607119 | 0.69 | LTB4R (0.48) | ROCK2LTB4RNAMPTALDH1A1LMNA | |
| SCHEMBL19695907 | 0.69 | LTB4R (0.52) | LTB4RALDH1A1HTTSMN1; SMN2PDE4D | |
| SCHEMBL19695909 | 0.69 | LTB4R (0.52) | LTB4RALDH1A1HTTSMN1; SMN2PDE4D | |
| SCHEMBL3932211 | 0.68 | KDM4C (0.44) | KDM4CALDH1A1LMNAGAAKDM4D | |
| SCHEMBL16703135 | 0.67 | KDM4C (0.58) | KDM4CKDM4DKDM6BKDM5AKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3485883-A1 | METHODS OF TREATING EYE DISEASES ASSOCIATED WITH INFLAMMATION AND VASCULAR PROLIFERATION | OccuRx Pty Ltd (AU) | 2019-05-22 | — | — | EP | disclosed |
| US-9839640-B2 | Methods of treating eye diseases associated with inflammation and vascular proliferation | OCCURX PTY LTD (AU) | 2017-12-12 | — | — | US | disclosed |