Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 1/20 | 0.48 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.45 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.41 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | RBP4 | P02753 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19695910 | 0.86 | KDM4C (0.42) | LTB4RALDH1A1PDE4APDE4BPDE4C | |
| SCHEMBL2950480 | 0.84 | LTB4R (0.61) | LTB4RMEN1ALDH1A1KMT2APDE4D | |
| SCHEMBL9607119 | 0.83 | LTB4R (0.48) | LTB4RALDH1A1DEGS1HCAR2RBP4 | |
| SCHEMBL19695909 | 0.81 | LTB4R (0.52) | LTB4RMEN1ALDH1A1KMT2APDE4D | |
| SCHEMBL19695907 | 0.81 | LTB4R (0.52) | LTB4RMEN1ALDH1A1KMT2APDE4D | |
| SCHEMBL19695945 | 0.80 | LTB4R (0.56) | LTB4RMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL19695908 | 0.79 | LTB4R (0.36) | LTB4RALDH1A1DEGS1HCAR2PDE4A | |
| SCHEMBL6790187 | 0.78 | HCAR2 (0.63) | LTB4RMEN1KMT2ADEGS1HCAR2 | |
| SCHEMBL6790194 | 0.78 | HCAR2 (0.63) | LTB4RMEN1KMT2ADEGS1HCAR2 | |
| SCHEMBL6790198 | 0.78 | HCAR2 (0.63) | LTB4RMEN1KMT2ADEGS1HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3485883-A1 | METHODS OF TREATING EYE DISEASES ASSOCIATED WITH INFLAMMATION AND VASCULAR PROLIFERATION | OccuRx Pty Ltd (AU) | 2019-05-22 | — | — | EP | disclosed |
| US-9839640-B2 | Methods of treating eye diseases associated with inflammation and vascular proliferation | OCCURX PTY LTD (AU) | 2017-12-12 | — | — | US | disclosed |
| WO-2010144959-A1 | ANALOGUES OF ANTI-FIBROTIC AGENTS | FIBROTECH THERAPEUTICS PTY LTD (AU) | 2010-12-23 | — | — | WO | disclosed |