Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 7/20 | 0.61 |
| ▸ | CES2 | O00748 | 2/20 | 0.47 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.40 |
| ▸ | PSMB11 | A5LHX3 | 3/20 | 0.38 |
| ▸ | PSMA7 | O14818 | 3/20 | 0.38 |
| ▸ | PSMB1 | P20618 | 3/20 | 0.38 |
| ▸ | PSMA1 | P25786 | 3/20 | 0.38 |
| ▸ | PSMA2 | P25787 | 3/20 | 0.38 |
| ▸ | PSMA3 | P25788 | 3/20 | 0.38 |
| ▸ | PSMA4 | P25789 | 3/20 | 0.38 |
| ▸ | PSMB8 | P28062 | 3/20 | 0.38 |
| ▸ | PSMB9 | P28065 | 3/20 | 0.38 |
| ▸ | PSMA5 | P28066 | 3/20 | 0.38 |
| ▸ | PSMB4 | P28070 | 3/20 | 0.38 |
| ▸ | PSMB6 | P28072 | 3/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.38 |
| ▸ | PSMB10 | P40306 | 3/20 | 0.38 |
| ▸ | PSMB3 | P49720 | 3/20 | 0.38 |
| ▸ | PSMB2 | P49721 | 3/20 | 0.38 |
| ▸ | PSMA6 | P60900 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22717043 | 1.00 | PDE2A (0.61) | PDE2ACES2LIPGPSMB11PSMA7 | |
| SCHEMBL23675536 | 1.00 | PDE2A (0.61) | PDE2ACES2LIPGPSMB11PSMA7 | |
| SCHEMBL19898274 | 0.85 | PDE2A (0.66) | PDE2ACES2LIPGSCN10AAR | |
| SCHEMBL12868145 | 0.84 | PDE2A (0.46) | PDE2ACES2HTR2AHTR2CHTR2B | |
| SCHEMBL2964976 | 0.84 | CES2 (0.50) | PDE2ACES2ORAI1ORAI2ORAI3 | |
| SCHEMBL2882405 | 0.81 | PDE2A (0.43) | PDE2ACES2SCN10AHTR2AHTR2C | |
| SCHEMBL22717245 | 0.81 | P2RX7 (0.47) | PDE2ACES2ARCYP3A4CYP2D6 | |
| SCHEMBL14121100 | 0.81 | PDE2A (0.43) | PDE2ACES2SCN10AHTR2AHTR2C | |
| SCHEMBL14121399 | 0.81 | PDE2A (0.43) | PDE2ACES2SCN10AHTR2AHTR2C | |
| SCHEMBL17025293 | 0.81 | PDE2A (0.61) | PDE2ALIPGSCN10AHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9840512-B2 | Antidiabetic bicyclic compounds | MERCK SHARP & DOHME CORP. (US) | 2017-12-12 | — | — | US | disclosed |