Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 6/20 | 0.73 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.56 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.56 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.54 |
| ▸ | JAK3 | P52333 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | NOS1 | P29475 | 1/20 | 0.50 |
| ▸ | CDC7 | O00311 | 1/20 | 0.50 |
| ▸ | CAMKK2 | Q96RR4 | 3/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.49 |
| ▸ | GSK3B | P49841 | 2/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14705835 | 0.87 | ABL1 (0.58) | ADORA1 | |
| SCHEMBL19706542 | 0.86 | ADORA1 (0.60) | ADORA1ADORA2AADORA3MAPK8MAPK10 | |
| SCHEMBL19706531 | 0.84 | NPC1 (0.71) | ADORA1ADORA2AADORA3MAPK8MAPK10 | |
| SCHEMBL6502989 | 0.84 | ADORA1 (1.00) | ADORA1ADORA2AADORA3NOS1 | |
| SCHEMBL5470852 | 0.80 | ADORA1 (0.69) | ADORA1ADORA2AADORA3MAPK8MAPK10 | |
| SCHEMBL19699600 | 0.78 | MKNK1 (0.55) | ADORA1JAK2JAK3CDC7 | |
| SCHEMBL27342102 | 0.77 | ADORA1 (0.65) | ADORA1ADORA2AADORA3NPC1RAB9A | |
| SCHEMBL22186399 | 0.76 | KDM4E (0.65) | ADORA1ADORA2AADORA3NPC1RAB9A | |
| SCHEMBL29091384 | 0.76 | MAPK8 (0.56) | ADORA2AMAPK8MAPK10JAK2JAK3 | |
| SCHEMBL19699460 | 0.76 | L3MBTL1 (0.51) | ADORA1NPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170355705-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2017-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170355705-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | ADORA1 2592/4885ADORA2A 3217/4885ADORA3 3318/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.