Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | DPP4 | P27487 | 2/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | GPX4 | P36969 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19701745 | 1.00 | ALDH1A1 (0.42) | ALDH1A1L3MBTL1LMNAKMT2AHCAR2 | |
| SCHEMBL18288681 | 0.93 | ALDH1A1 (0.46) | ALDH1A1L3MBTL1LMNAKMT2AHCAR2 | |
| SCHEMBL18288705 | 0.92 | ALDH1A1 (0.46) | ALDH1A1L3MBTL1LMNAKMT2AHCAR2 | |
| SCHEMBL2609712 | 0.84 | SMN1; SMN2 (0.43) | ALDH1A1L3MBTL1HCAR2KEAP1NFE2L2 | |
| SCHEMBL2609715 | 0.84 | SMN1; SMN2 (0.43) | ALDH1A1L3MBTL1HCAR2KEAP1NFE2L2 | |
| SCHEMBL18288709 | 0.84 | ALDH1A1 (0.43) | ALDH1A1L3MBTL1LMNAKMT2AKDM4E | |
| SCHEMBL6598455 | 0.78 | L3MBTL1 (0.41) | ALDH1A1L3MBTL1LMNAKMT2AMAPT | |
| SCHEMBL18292237 | 0.77 | SMN1; SMN2 (0.47) | ALDH1A1L3MBTL1KMT2AKDM4EHTT | |
| SCHEMBL18288694 | 0.75 | LMNA (0.38) | ALDH1A1L3MBTL1LMNAKMT2AHCAR2 | |
| SCHEMBL18199366 | 0.74 | HCAR2 (0.38) | ALDH1A1L3MBTL1LMNAHCAR2KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180000770-A1 | Methods of Treating Multiple Sclerosis | BIOGEN MA INC (US) | 2018-01-04 | — | — | US | disclosed |
| US-20170368013-A1 | Methods of Treating Multiple Sclerosis | BIOGEN MA INC. | 2017-12-28 | — | — | US | disclosed |
| US-20170354630-A1 | Methods of Treating Multiple Sclerosis | BIOGEN MA INC. | 2017-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170368013-A1 | Methods of Treating Multiple Sclerosis | FAH, FH, PML | ALDH1A1 3424/4885L3MBTL1 1836/4885LMNA 3109/4885 |
| US-20180000770-A1 | Methods of Treating Multiple Sclerosis | FAH, FH, PML | ALDH1A1 3424/4885L3MBTL1 1836/4885LMNA 3109/4885 |
| US-20170354630-A1 | Methods of Treating Multiple Sclerosis | FAH, FH, PML | ALDH1A1 3424/4885L3MBTL1 1836/4885LMNA 3109/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.