Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 17/20 | 0.61 |
| ▸ | ADAM17 | P78536 | 9/20 | 0.52 |
| ▸ | MMP2 | P08253 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23901420 | 0.85 | ADAMTS5 (0.71) | ADAMTS5ADAM17MMP2 | |
| SCHEMBL19691953 | 0.84 | ADAMTS5 (0.74) | ADAMTS5ADAM17MMP2 | |
| SCHEMBL21693594 | 0.79 | ADAM17 (0.77) | ADAMTS5ADAM17 | |
| SCHEMBL21693600 | 0.78 | ADAM17 (0.57) | ADAMTS5ADAM17MMP2 | |
| SCHEMBL23901405 | 0.77 | ADAMTS5 (0.71) | ADAMTS5ADAM17MMP2 | |
| SCHEMBL22063672 | 0.76 | ADAM17 (0.54) | ADAMTS5ADAM17 | |
| SCHEMBL19996688 | 0.76 | ADAMTS5 (0.71) | ADAMTS5ADAM17MMP2 | |
| SCHEMBL19691598 | 0.76 | ADAMTS5 (1.00) | ADAMTS5MMP2 | |
| SCHEMBL19996668 | 0.75 | ADAMTS5 (0.59) | ADAMTS5MMP2 | |
| SCHEMBL19703100 | 0.75 | ADAM17 (0.76) | ADAMTS5ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3468961-B1 | 5-[3-[PIPERIDIN-1-YL]-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS 4 AND 5 INHIBITORS FOR TREATING E.G. OSTEOARTHRITIS | GALAPAGOS NV (BE) | 2020-06-10 | — | — | EP | disclosed |
| WO-2017211667-A1 | 5-[3-[PIPERIDIN-1-YL]-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS 4 AND 5 INHIBITORS FOR TREATING E.G. OSTEOARTHRITIS | GALAPAGOS NV (BE) | 2017-12-14 | — | — | WO | disclosed |