Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.64 |
| ▸ | HTT | P42858 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | NPC1 | O15118 | 2/20 | 0.64 |
| ▸ | RAB9A | P51151 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | ATM | Q13315 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 5/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13120863 | 0.83 | ALDH1A1 (0.49) | ALDH1A1HTTLMNANPC1RAB9A | |
| SCHEMBL8877711 | 0.73 | ALDH1A1 (0.55) | ALDH1A1HTTLMNANPC1RAB9A | |
| SCHEMBL23818010 | 0.73 | FNIP1 (0.58) | ALDH1A1HTTLMNANPC1RAB9A | |
| SCHEMBL25455117 | 0.69 | CTNNB1 (0.48) | ALDH1A1HTTLMNANPC1RAB9A | |
| SCHEMBL1336792 | 0.69 | ALDH1A1 (0.62) | ALDH1A1HTTLMNANPC1RAB9A | |
| SCHEMBL1336794 | 0.69 | ALDH1A1 (0.62) | ALDH1A1HTTLMNANPC1RAB9A | |
| SCHEMBL15055794 | 0.67 | ALDH1A1 (0.56) | ALDH1A1HTTLMNARAB9AMAPT | |
| SCHEMBL2720448 | 0.66 | TRPM8 (0.60) | LMNAMAPTPOLBTP53TRPM8 | |
| SCHEMBL4707186 | 0.66 | TRPM8 (0.60) | ALDH1A1HTTLMNANPC1RAB9A | |
| SCHEMBL2419952 | 0.66 | THRB (0.74) | ALDH1A1HTTLMNANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2334301-B1 | MACROCYCLICS PYRIMIDINES AS AURORA KINASE INHIBITORS | MERCK SERONO SA (CH) | 2018-02-14 | — | — | EP | disclosed |
| US-8815872-B2 | Macrocyclics pyrimidines as aurora kinase inhibitors | MERCK PATENT GMBH (DE) | 2014-08-26 | — | — | US | disclosed |
| US-20110294801-A1 | MACROCYCLICS PYRIMIDINES AS AURORA KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2011-12-01 | — | — | US | disclosed |
| CN-102143750-A | Macrocyclics pyrimidines as aurora kinase inhibitors | MERCK PATENT GMBH | 2011-08-03 | — | — | CN | disclosed |
| EP-2334301-A1 | MACROCYCLICS PYRIMIDINES AS AURORA KINASE INHIBITORS | Merck Serono SA (CH) | 2011-06-22 | — | — | EP | disclosed |
| WO-2010028116-A1 | MACROCYCLICS PYRIMIDINES AS AURORA KINASE INHIBITORS | MERCK SERONO S.A. (CH) | 2010-03-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110294801-A1 | MACROCYCLICS PYRIMIDINES AS AURORA KINASE INHIBITORS | AURKC, AURKA, AURKB | ALDH1A1 4424/4885HTT 4089/4885LMNA 2969/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.