Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1970585 | 0.83 | ALDH1A1 (0.64) | ALDH1A1KMT2AMEN1POLBHTT | |
| SCHEMBL6837468 | 0.81 | LMNA (0.40) | POLBMAPTLMNATP53THRB | |
| SCHEMBL14303519 | 0.73 | ALDH1A1 (0.39) | ALDH1A1KMT2AMEN1POLBHTT | |
| SCHEMBL14267707 | 0.72 | SIGMAR1 (0.48) | ALDH1A1KMT2AMEN1HTTMAPT | |
| SCHEMBL6955778 | 0.70 | ALDH1A1 (0.48) | ALDH1A1KMT2AMEN1POLBHTT | |
| SCHEMBL3441758 | 0.69 | PYCR1 (0.53) | ALDH1A1KMT2AMEN1POLBHTT | |
| SCHEMBL6963390 | 0.69 | ALDH1A1 (0.59) | ALDH1A1KMT2AMEN1HTTPKM | |
| SCHEMBL1336792 | 0.68 | ALDH1A1 (0.62) | ALDH1A1KMT2AMEN1POLBHTT | |
| SCHEMBL1336794 | 0.68 | ALDH1A1 (0.62) | ALDH1A1KMT2AMEN1POLBHTT | |
| SCHEMBL16366561 | 0.67 | ALDH1A1 (0.50) | ALDH1A1KMT2AMEN1POLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7812038-B2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2010-10-12 | — | — | US | disclosed |
| US-7812038-B2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2010-10-12 | — | — | US | disclosed |