Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 8/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11442252 | 0.74 | CHRM2 (0.36) | KCNH2HRH3KMT2AMEN1LMNA | |
| SCHEMBL11437822 | 0.74 | MEN1 (0.42) | KMT2AMEN1 | |
| SCHEMBL30556459 | 0.68 | KCNH2 (0.66) | KCNH2HRH3RAB9AKMT2ANPC1 | |
| SCHEMBL19707207 | 0.66 | RAB9A (0.47) | RAB9AKMT2ANPC1MEN1EPHX1 | |
| SCHEMBL29605135 | 0.65 | PTPN1 (0.74) | RAB9AKMT2ANPC1MEN1EPHX1 | |
| SCHEMBL1171515 | 0.65 | RAB9A (0.56) | RAB9AKMT2ANPC1MEN1EPHX1 | |
| SCHEMBL19707634 | 0.64 | RAB9A (0.50) | KCNH2HRH3RAB9AKMT2ANPC1 | |
| SCHEMBL9547525 | 0.64 | ATM (0.66) | KCNH2HRH3RAB9AKMT2ANPC1 | |
| SCHEMBL16823328 | 0.64 | KCNA5 (0.52) | RAB9ANPC1EPHX1 | |
| SCHEMBL148345 | 0.64 | MEN1 (0.68) | KMT2AMEN1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017214505-A1 | CERAMIDE GALACTOSYLTRANSFERASE INHIBITORS FOR THE TREATMENT OF DISEASE | BIOMARIN PHARMACEUTICAL INC. (US) | 2017-12-14 | — | — | WO | disclosed |