SCHEMBL19707682

SCHEMBL19707682

O=C(NCc1ccc2c(c1)CCN2)c1ccc(F)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.52
ACHE P22303 1/20 0.49
LMNA P02545 5/20 0.49
MAPK14 Q16539 2/20 0.46
CYP3A4 P08684 1/20 0.46
ROCK2 O75116 1/20 0.46
HDAC3 O15379 1/20 0.46
HDAC4 P56524 1/20 0.46
HDAC1 Q13547 1/20 0.46
HDAC7 Q8WUI4 1/20 0.46
HDAC2 Q92769 1/20 0.46
HDAC10 Q969S8 1/20 0.46
HDAC11 Q96DB2 1/20 0.46
HDAC8 Q9BY41 1/20 0.46
HDAC6 Q9UBN7 1/20 0.46
HDAC9 Q9UKV0 1/20 0.46
HDAC5 Q9UQL6 1/20 0.46
NCOR2 Q9Y618 1/20 0.46
THRB P10828 2/20 0.46
TP53 P04637 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25781080 0.88 IDO1 (0.51) ACHEMAPK14CYP3A4ROCK2THRB
SCHEMBL27370813 0.85 KDM4E (0.54) L3MBTL1ACHELMNAROCK2KDM4E
SCHEMBL3423525 0.84 EPHX2 (0.57) ACHELMNAMAPK14TP53
SCHEMBL19260062 0.80 RAB9A (0.52) ACHELMNAROCK2HDAC2HDAC8
SCHEMBL5773625 0.79 GAA (0.52) L3MBTL1LMNAMAPK14CYP3A4ROCK2
SCHEMBL19689738 0.78 MAPT (0.51) THRBKDM4EALDH1A1
SCHEMBL6210414 0.77 NR1H4 (0.52) MAPK14HDAC3HDAC4HDAC1HDAC7
SCHEMBL6077802 0.76 L3MBTL1 (0.77) L3MBTL1LMNAMAPK14CYP3A4HDAC3
SCHEMBL3425707 0.75 EPHX2 (0.47) TP53
SCHEMBL6213479 0.75 NR1H4 (0.47) MAPK14HDAC3HDAC4HDAC1HDAC7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017213919-A1 1-TETRAHYDROPYRANYLCARBONYL-2,3-DIHYDRO-1H-INDOLE COMPOUNDS FOR TREATING CANCER ELI LILLY AND COMPANY (US) 2017-12-14 WO disclosed