Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MMP13 | P45452 | 4/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.50 |
| ▸ | PRKCG | P05129 | 2/20 | 0.50 |
| ▸ | AKT1 | P31749 | 2/20 | 0.50 |
| ▸ | SGK1 | O00141 | 1/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.50 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.50 |
| ▸ | AKT2 | P31751 | 1/20 | 0.50 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.50 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19260062 | 0.88 | RAB9A (0.52) | ROCK2PRKCGAKT1MAPK1MAPK3 | |
| SCHEMBL6981710 | 0.81 | KDM4E (0.60) | ROCK2PRKCGAKT1MAPK1MAPK3 | |
| SCHEMBL27370813 | 0.79 | KDM4E (0.54) | ROCK2LMNASMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL28523618 | 0.79 | KDM4E (0.49) | GSK3BALDH1A1 | |
| SCHEMBL25781080 | 0.79 | IDO1 (0.51) | ROCK2CYP3A4MAPK14HTTSMN1; SMN2 | |
| SCHEMBL19707682 | 0.79 | L3MBTL1 (0.52) | ROCK2CYP3A4MAPK14LMNAALDH1A1 | |
| SCHEMBL23063877 | 0.77 | ALDH1A1 (0.54) | GAAMMP13ROCK2MAPK1CA2 | |
| SCHEMBL31253145 | 0.77 | ALDH1A1 (0.54) | GAAMMP13ROCK2MAPK1CA2 | |
| SCHEMBL2927034 | 0.74 | EPHX2 (0.55) | ROCK2ROCK1 | |
| SCHEMBL1569157 | 0.74 | L3MBTL1 (0.77) | GAAMMP13ROCK2PRKCGAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003721-B1 | BENZYLIDENE-1,3-DIHYDRO-INDOL-2-ONE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS, PARTICULARLY OF RAF KINASES | GLAXO GROUP LTD (GB) | 2006-11-02 | — | — | EP | disclosed |