Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | F3 | P13726 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.41 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.41 |
| ▸ | PPIA | P62937 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19707682 | 0.78 | L3MBTL1 (0.52) | KDM4EALDH1A1THRB | |
| SCHEMBL19689659 | 0.72 | MAPT (0.88) | MAPTPOLB | |
| SCHEMBL19689645 | 0.71 | MAPT (0.73) | MAPTPOLBTHRB | |
| SCHEMBL19689633 | 0.71 | MAPT (0.70) | MAPTPOLBTHRB | |
| SCHEMBL19708625 | 0.70 | MAPT (0.69) | MAPTPOLBTHRB | |
| SCHEMBL549063 | 0.68 | DRD2 (0.59) | MAPTPARP1KDM4EALDH1A1HTT | |
| SCHEMBL27193044 | 0.68 | RAB9A (0.77) | MAPTRAB9ANPC1KDM4EALDH1A1 | |
| SCHEMBL5800735 | 0.68 | GAA (0.58) | RAB9AMEN1KMT2ANPC1KDM4E | |
| SCHEMBL25781080 | 0.68 | IDO1 (0.51) | MAPTRAB9AMEN1KMT2AHTT | |
| SCHEMBL24449105 | 0.68 | ALDH1A1 (0.46) | MAPTRAB9AKDM4EALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109641881-B | 1-tetrahydropyranyl carbonyl-2, 3-dihydro-1H-indole compounds for use in the treatment of cancer | 伊莱利利公司 | 2022-01-07 | — | — | CN | disclosed |
| US-10759786-B2 | 1-tetrahydropyranylcarbonyl-2,3-dihydro-1H-indole compounds for treating cancer | ELI LILLY AND COMPANY (US) | 2020-09-01 | — | — | US | disclosed |
| EP-3468965-B1 | 1-TETRAHYDROPYRANYLCARBONYL-2,3-DIHYDRO-1H-INDOLE COMPOUNDS FOR TREATING CANCER | LILLY CO ELI (US) | 2020-04-29 | — | — | EP | disclosed |
| US-20190161477-A1 | 1-TETRAHYDROPYRANYLCARBONYL-2,3-DIHYDRO-IH-INDOLE COMPOUNDS FOR TREATING CANCER | ELI LILLY AND COMPANY | 2019-05-30 | — | — | US | disclosed |
| EP-3468965-A1 | 1-TETRAHYDROPYRANYLCARBONYL-2,3-DIHYDRO-1H-INDOLE COMPOUNDS FOR TREATING CANCER | Eli Lilly and Company (US) | 2019-04-17 | — | — | EP | disclosed |
| US-9872853-B2 | 2,3-dihydro-1H-indole compounds | ELI LILLY AND COMPANY (US) | 2018-01-23 | — | — | US | disclosed |
| US-20170354641-A1 | 2,3-DIHYDRO-1H-INDOLE COMPOUNDS | ELI LILLY AND COMPANY | 2017-12-14 | — | — | US | disclosed |
| WO-2017213919-A1 | 1-TETRAHYDROPYRANYLCARBONYL-2,3-DIHYDRO-1H-INDOLE COMPOUNDS FOR TREATING CANCER | ELI LILLY AND COMPANY (US) | 2017-12-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190161477-A1 | 1-TETRAHYDROPYRANYLCARBONYL-2,3-DIHYDRO-IH-INDOLE COMPOUNDS FOR TREATING CANCER | MCL1, IDO1, GLI1 | MAPT 3345/4885RAB9A 3450/4885MEN1 255/4885 |
| US-10759786-B2 | 1-tetrahydropyranylcarbonyl-2,3-dihydro-1H-indole compounds for treating cancer | MCL1, FOXM1, IDO1 | MAPT 3015/4885RAB9A 3196/4885MEN1 189/4885 |
| US-20170354641-A1 | 2,3-DIHYDRO-1H-INDOLE COMPOUNDS | MCL1, IDO1, IDO2 | MAPT 3006/4885RAB9A 2836/4885MEN1 275/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.