Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.77 |
| ▸ | RAB9A | P51151 | 1/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.68 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | SMYD3 | Q9H7B4 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | POLB | P06746 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19710243 | 0.88 | L3MBTL1 (0.80) | L3MBTL1RAB9ASMYD3KMT2AMEN1 | |
| SCHEMBL17591888 | 0.87 | L3MBTL1 (1.00) | L3MBTL1SMYD3KMT2AMEN1ALDH1A1 | |
| SCHEMBL19710586 | 0.84 | SMYD3 (0.69) | L3MBTL1RAB9ACYP3A4GAASMYD3 | |
| SCHEMBL19710430 | 0.83 | L3MBTL1 (0.72) | L3MBTL1GAASMYD3KMT2AMEN1 | |
| SCHEMBL19710242 | 0.79 | L3MBTL1 (0.66) | L3MBTL1GAASMYD3KMT2AMEN1 | |
| SCHEMBL164793 | 0.78 | NAMPT (0.80) | — | |
| SCHEMBL19710245 | 0.77 | SMYD3 (0.68) | L3MBTL1CYP3A4GAASMYD3KMT2A | |
| SCHEMBL28683089 | 0.77 | SMN1; SMN2 (0.59) | L3MBTL1RAB9AGAAKMT2AMEN1 | |
| SCHEMBL19710587 | 0.76 | SMYD3 (1.00) | L3MBTL1GAASMYD3KMT2AMEN1 | |
| SCHEMBL3955552 | 0.75 | ALDH1A1 (0.62) | L3MBTL1RAB9AKMT2AALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210198252-A1 | SMYD INHIBITORS | EPIZYME INC (US) | 2021-07-01 | — | — | US | claimed |
| US-20190322660-A1 | SMYD INHIBITORS | Epizyme, Inc. | 2019-10-24 | — | — | US | claimed |
| US-20210198252-A1 | SMYD INHIBITORS | EPIZYME INC (US) | 2021-07-01 | — | — | US | disclosed |
| US-20190322660-A1 | SMYD INHIBITORS | Epizyme, Inc. | 2019-10-24 | — | — | US | disclosed |
| US-10266526-B2 | Substituted 1,2,3-triazoles as SMYD inhibitors for treating cancer | Epizyme, Inc. (US) | 2019-04-23 | — | — | US | disclosed |
| US-20170355695-A1 | SMYD Inhibitors | Epizyme, Inc. (US) | 2017-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10266526-B2 | Substituted 1,2,3-triazoles as SMYD inhibitors for treating cancer | SMYD3, SMYD2, SNRPD3 | L3MBTL1 632/4885RAB9A 1388/4885CYP3A4 3384/4885 |
| US-20170355695-A1 | SMYD Inhibitors | SMYD3, SMYD2, SMURF2 | L3MBTL1 660/4885RAB9A 893/4885CYP3A4 4188/4885 |
| US-20210198252-A1 | SMYD INHIBITORS | SMYD3, SMYD2, SMURF2 | L3MBTL1 659/4885RAB9A 890/4885CYP3A4 4238/4885 |
| US-20190322660-A1 | SMYD INHIBITORS | SMYD2, SMYD3, SMURF2 | L3MBTL1 443/4885RAB9A 736/4885CYP3A4 3863/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.