Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QDPR | P09417 | 2/20 | 0.61 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.56 |
| ▸ | HTR2C | P28335 | 2/20 | 0.53 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.51 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.51 |
| ▸ | LIPE | Q05469 | 1/20 | 0.50 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.49 |
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
| ▸ | MMP9 | P14780 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 5/20 | 0.48 |
| ▸ | DRD2 | P14416 | 4/20 | 0.48 |
| ▸ | DRD3 | P35462 | 3/20 | 0.48 |
| ▸ | USP5 | P45974 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16785547 | 0.91 | NPC1 (0.56) | QDPRMCHR1HTR2CADAM17ADAMTS5 | |
| SCHEMBL7482001 | 0.84 | QDPR (0.66) | QDPRDRD4DRD2DRD3DRD1 | |
| SCHEMBL19658654 | 0.83 | QDPR (0.60) | QDPRADAMTS5LIPENPC1DRD4 | |
| SCHEMBL2651932 | 0.83 | QDPR (0.60) | QDPRMCHR1SOS1 | |
| SCHEMBL1091809 | 0.83 | QDPR (0.60) | QDPRMCHR1TP53DRD4DRD2 | |
| SCHEMBL1473424 | 0.82 | QDPR (0.61) | QDPRNPC1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL14590572 | 0.81 | QDPR (0.61) | QDPRHTR2CDRD2USP5 | |
| SCHEMBL27304673 | 0.81 | QDPR (0.69) | QDPRMCHR1LIPEDRD2 | |
| SCHEMBL5670914 | 0.81 | QDPR (0.57) | QDPRLIPEADAM10MMP2SOS1 | |
| SCHEMBL30563607 | 0.80 | GPR119 (0.65) | TP53MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3209664-B1 | BICYCLIC HETEROARYL AMINE COMPOUNDS AS PI3K INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2020-06-03 | — | — | EP | disclosed |
| US-20170355707-A1 | BICYCLIC HETEROARYL AMINE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2017-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170355707-A1 | BICYCLIC HETEROARYL AMINE COMPOUNDS | PIK3R3, JAK2, JAK3 | QDPR 2037/4885MCHR1 3120/4885HTR2C 1061/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.