Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19701973 | 0.83 | PIK3CD (0.39) | SMN1; SMN2PIK3CDCYP2C9CYP1A2HSD17B10 | |
| SCHEMBL9018985 | 0.76 | SMN1; SMN2 (0.59) | SMN1; SMN2KDM4ENPC1RAB9ADPP4 | |
| SCHEMBL19710656 | 0.75 | PIK3CD (0.48) | NPC1RAB9ADPP4PIK3CDCYP1A2 | |
| SCHEMBL19710651 | 0.72 | PIK3CD (0.44) | SMN1; SMN2PIK3CDCYP2C9CYP1A2HSD17B10 | |
| SCHEMBL19710647 | 0.72 | TSHR (0.44) | RAB9AHSD17B10ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL19710839 | 0.71 | PIK3CD (0.44) | RAB9APIK3CDHSD17B10ALDH1A1MAPT | |
| SCHEMBL25088685 | 0.70 | L3MBTL1 (0.46) | SMN1; SMN2KDM4ENPC1RAB9ADPP4 | |
| SCHEMBL19710856 | 0.68 | HTR7 (0.47) | SMN1; SMN2KDM4ENPC1RAB9ADPP4 | |
| SCHEMBL15829985 | 0.64 | ALDH1A1 (0.57) | SMN1; SMN2KDM4EALDH1A1MAPTRECQL | |
| SCHEMBL8324269 | 0.63 | LMNA (0.32) | SMN1; SMN2CYP2C9CYP1A2HSD17B10USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170355707-A1 | BICYCLIC HETEROARYL AMINE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2017-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170355707-A1 | BICYCLIC HETEROARYL AMINE COMPOUNDS | PIK3R3, JAK2, JAK3 | SMN1; SMN2 4355/4885KDM4E 2233/4885NPC1 3573/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.