Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 8/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | DAGLB | Q8NCG7 | 2/20 | 0.45 |
| ▸ | DAGLA | Q9Y4D2 | 2/20 | 0.45 |
| ▸ | CHI3L1 | P36222 | 1/20 | 0.43 |
| ▸ | CHIT1 | Q13231 | 1/20 | 0.43 |
| ▸ | CHI3L2 | Q15782 | 1/20 | 0.43 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | DDHD2 | O94830 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13070080 | 0.84 | HRH4 (0.50) | SLC6A4SLC6A3TDP1L3MBTL1ALDH1A1 | |
| SCHEMBL1966648 | 0.81 | TAAR1 (0.47) | SLC6A4CHI3L1CHIT1CHI3L2CHIA | |
| SCHEMBL1966332 | 0.81 | AOC3 (0.59) | SLC6A4SLC6A3 | |
| SCHEMBL4715512 | 0.81 | SLC6A4 (0.48) | SLC6A4SLC6A3TDP1L3MBTL1DAGLB | |
| SCHEMBL5667997 | 0.80 | SLC6A4 (0.58) | SLC6A4SLC6A3ALDH1A1TSHR | |
| Hydrochloric Acid SCHEMBL8508484 | 0.79 | SLC6A4 (0.57) | SLC6A4SLC6A3ALDH1A1TSHR | |
| SCHEMBL1968987 | 0.79 | CHIA (0.54) | CHI3L1CHIT1CHI3L2CHIAHTR2A | |
| SCHEMBL1969047 | 0.77 | TAAR1 (0.60) | CHI3L1CHIT1CHI3L2CHIATSHR | |
| SCHEMBL1967611 | 0.75 | CHIA (0.54) | CHI3L1CHIT1CHI3L2CHIAHTR2A | |
| SCHEMBL12891009 | 0.74 | CHIT1 (0.57) | CHI3L1CHIT1CHI3L2CHIAHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110212968-A1 | PHENETHYLAMIDE DERIVATIVES AND THEIR HETEROCYCLIC ANALOGUES | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-09-01 | — | — | US | disclosed |
| CN-102164896-A | Phenethylamide derivatives and their heterocyclic analogues | ACTELION PHARMACEUTICALS LTD | 2011-08-24 | — | — | CN | disclosed |
| EP-2334643-A1 | PHENETHYLAMIDE DERIVATIVES AND THEIR HETEROCYCLIC ANALOGUES | Actelion Pharmaceuticals Ltd. (CH) | 2011-06-22 | — | — | EP | disclosed |
| WO-2010044054-A1 | PHENETHYLAMIDE DERIVATIVES AND THEIR HETEROCYCLIC ANALOGUES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-04-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110212968-A1 | PHENETHYLAMIDE DERIVATIVES AND THEIR HETEROCYCLIC ANALOGUES | HCRTR2, HCRTR1, HRH3 | SLC6A4 781/4885SLC6A3 576/4885TDP1 4608/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.