Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.44 |
| ▸ | LSS | P48449 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | GCGR | P47871 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1971365 | 0.84 | SLC6A4 (0.54) | TDP1L3MBTL1SLC6A4TSHRALDH1A1 | |
| SCHEMBL2056224 | 0.79 | SLC6A4 (0.66) | HRH3SLC6A4TSHRALDH1A1SLC6A3 | |
| SCHEMBL13074386 | 0.79 | SLC6A4 (0.57) | SLC6A4TSHRALDH1A1SLC6A3LSS | |
| SCHEMBL19733792 | 0.79 | SLC6A4 (0.40) | TDP1L3MBTL1SLC6A4TSHRALDH1A1 | |
| SCHEMBL13157801 | 0.76 | SLC6A4 (0.54) | SLC6A4TSHRALDH1A1SCN9ASLC6A3 | |
| SCHEMBL24780826 | 0.76 | ALDH1A1 (0.60) | SLC6A4TSHRALDH1A1SLC6A3LSS | |
| SCHEMBL13452623 | 0.75 | HRH3 (0.59) | HRH4HRH3TDP1SLC6A4SLC6A3 | |
| SCHEMBL8825962 | 0.75 | LTA4H (0.54) | HRH4HRH3SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL3397214 | 0.75 | PYCR1 (0.41) | SLC6A4TSHRALDH1A1SCN9ALSS | |
| SCHEMBL2404203 | 0.75 | CCR5 (0.65) | HRH3TDP1L3MBTL1GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2246329-A1 | 4(1H)-pyridinone derivatives and their use as antimalaria agents | Glaxo Group Limited (GB) | 2010-11-03 | — | — | EP | disclosed |
| WO-2010081904-A1 | 4 ( 1H) -PYRIDINONE DERIVATIVES AND THEIR USE AS ANTIMALARIA AGENTS | GLAXO GROUP LIMITED (GB) | 2010-07-22 | — | — | WO | disclosed |