Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 4/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.48 |
| ▸ | DAGLA | Q9Y4D2 | 4/20 | 0.46 |
| ▸ | DAGLB | Q8NCG7 | 3/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.44 |
| ▸ | CCR5 | P51681 | 2/20 | 0.44 |
| ▸ | DDHD2 | O94830 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | LSS | P48449 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4715365 | 0.82 | AGTR2 (0.47) | CHRM4MCHR1L3MBTL1 | |
| SCHEMBL1971365 | 0.81 | SLC6A4 (0.54) | SLC6A4SLC6A3DAGLADAGLBCHRM4 | |
| SCHEMBL4716374 | 0.76 | CCR5 (0.42) | CCR5L3MBTL1TDP1HRH3 | |
| SCHEMBL3320631 | 0.76 | CCR5 (0.43) | CHRM4CCR5MCHR1L3MBTL1TDP1 | |
| SCHEMBL27144034 | 0.74 | CARM1 (0.49) | HRH3 | |
| SCHEMBL16963832 | 0.72 | ENPP2 (0.48) | HRH3 | |
| SCHEMBL5667997 | 0.71 | SLC6A4 (0.58) | SLC6A4SLC6A3HRH3 | |
| Hydrochloric Acid SCHEMBL8508484 | 0.70 | SLC6A4 (0.57) | SLC6A4SLC6A3HRH3 | |
| SCHEMBL4711078 | 0.69 | L3MBTL1 (0.42) | L3MBTL1TDP1 | |
| SCHEMBL29056938 | 0.69 | L3MBTL1 (0.66) | L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1933830-A1 | ANTAGONISTS OF SNS SODIUM CHANNELS | Vernalis (R&D) Limited (GB) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007007057-A1 | ANTAGONISTS OF SNS SODIUM CHANNELS | VERNALIS (R & D) LIMITED (GB) | 2007-01-18 | — | — | WO | disclosed |