Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MPO | P05164 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19714478 | 0.86 | LMNA (0.74) | LMNAMAPTSMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL19714285 | 0.84 | POLB (0.59) | LMNAMAPTSMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL19714625 | 0.83 | TP53 (0.62) | LMNAMAPTSMN1; SMN2RAB9APOLB | |
| SCHEMBL19714573 | 0.83 | USP2 (0.61) | LMNAMAPTSMN1; SMN2USP2RAB9A | |
| SCHEMBL20715313 | 0.82 | MAPT (0.62) | LMNAMAPTCYP2C19ALDH1A1MPO | |
| SCHEMBL19714466 | 0.80 | KMT2A (0.65) | LMNAMAPTSMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL17833385 | 0.80 | LMNA (0.60) | LMNAMAPTSMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL19714100 | 0.80 | LMNA (0.73) | LMNAMAPTSMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL17824312 | 0.79 | RAB9A (0.64) | LMNAMAPTSMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL19714456 | 0.78 | MEN1 (0.54) | LMNAMAPTSMN1; SMN2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170362184-A1 | PRO-SURVIVAL COMPOUNDS | HERIOT-WATT UNIVERSITY (GB) | 2017-12-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170362184-A1 | PRO-SURVIVAL COMPOUNDS | MCL1, MKI67, MORF4L1 | LMNA 301/4885MAPT 4635/4885SMN1; SMN2 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.