Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.38 |
| ▸ | PCNA | P12004 | 1/20 | 0.37 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15851321 | 0.85 | EGFR (0.38) | EGFRCYP3A4MTNR1AMTNR1BNQO2 | |
| SCHEMBL15851331 | 0.85 | EGFR (0.38) | EGFRCYP3A4MTNR1AMTNR1BNQO2 | |
| SCHEMBL15962606 | 0.83 | CA12 (0.41) | EGFRPCNAKDM4EALDH1A1LMNA | |
| SCHEMBL29286178 | 0.82 | SLC7A5 (0.38) | PCNASLC7A5LMNABLMKMT2A | |
| SCHEMBL23544355 | 0.82 | SLC7A5 (0.38) | PCNASLC7A5LMNABLMKMT2A | |
| SCHEMBL10564172 | 0.82 | ITGA4 (0.41) | SLC7A5KDM4EALDH1A1LMNAMAPT | |
| SCHEMBL10972221 | 0.81 | ALDH1A1 (0.39) | EGFRSLC7A5KDM4EALDH1A1LMNA | |
| SCHEMBL15856090 | 0.80 | CTSS (0.46) | NQO2ITGA4ITGB7 | |
| SCHEMBL15856088 | 0.80 | CTSS (0.46) | NQO2ITGA4ITGB7 | |
| SCHEMBL19720234 | 0.80 | CTSS (0.46) | NQO2ITGA4ITGB7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2940007-B1 | TYROSINE DERIVATIVE AND MANUFACTURING METHOD FOR TYROSINE DERIVATIVE | NARD INSTITUTE LTD (JP) | 2017-12-20 | — | — | EP | disclosed |