Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 15/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13157390 | 0.94 | TRPV4 (0.40) | TRPV4PAX8CYP3A4KCNH2 | |
| SCHEMBL19720319 | 0.89 | POLB (0.40) | TRPV4CYP3A4KCNH2CYP19A1 | |
| SCHEMBL11964603 | 0.85 | USP2 (0.44) | TRPV4HTR6ARCYP3A4 | |
| SCHEMBL13157501 | 0.84 | CYP3A4 (0.39) | TRPV4CYP3A4KCNH2CYP19A1 | |
| SCHEMBL19720296 | 0.84 | TSHR (0.41) | ARCYP19A1ALK | |
| SCHEMBL694514 | 0.83 | TRPV4 (0.43) | TRPV4ARCYP3A4KCNH2 | |
| SCHEMBL13157448 | 0.83 | MEN1 (0.43) | TRPV4CYP3A4KCNH2 | |
| SCHEMBL693745 | 0.82 | PAX8 (0.39) | TRPV4PAX8ARCYP3A4 | |
| SCHEMBL19720318 | 0.81 | PKM (0.38) | TRPV4ARCYP19A1 | |
| SCHEMBL19720294 | 0.81 | TRPV4 (0.34) | TRPV4ARCYP3A4KCNH2CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2749554-B1 | 2,5-disubstituted arylsulfonamide CCR3 antagonists | SMA THERAPEUTICS INC (US) | 2017-12-20 | — | — | EP | disclosed |