Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 5/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 2/20 | 0.38 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | CTSD | P07339 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19720587 | 0.85 | NR1D1 (0.42) | USP30GPR119JAK2JAK1KMT2A | |
| SCHEMBL19720631 | 0.81 | PDE4B (0.46) | USP30GPR119JAK2JAK1MEN1 | |
| SCHEMBL29480855 | 0.78 | USP30 (0.50) | USP30ALDH1A1 | |
| SCHEMBL16895681 | 0.78 | USP30 (0.50) | USP30ALDH1A1 | |
| SCHEMBL16895680 | 0.78 | USP30 (0.50) | USP30ALDH1A1 | |
| SCHEMBL19720772 | 0.77 | STS (0.43) | USP30GPR119JAK2JAK1MEN1 | |
| SCHEMBL19720770 | 0.77 | NR1D1 (0.45) | USP30MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL19720786 | 0.76 | OPRK1 (0.39) | USP30BACE1HDAC1HDAC2CTSD | |
| SCHEMBL19720594 | 0.73 | LMNA (0.40) | USP30GPR119MEN1KMT2AALDH1A1 | |
| SCHEMBL19720566 | 0.72 | USP30 (0.35) | USP30GPR119JAK2JAK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3257848-A1 | COMPOUNDS AND COMPOSITIONS FOR MODULATING EGFR ACTIVITY | Novartis AG (CH) | 2017-12-20 | — | — | EP | disclosed |