Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1D1 | P20393 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.38 |
| ▸ | BTK | Q06187 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19720770 | 0.90 | NR1D1 (0.45) | NR1D1MAPTALDH1A1LMNAUSP30 | |
| SCHEMBL19720586 | 0.85 | USP30 (0.43) | MAPTALDH1A1USP30GPR119KMT2A | |
| SCHEMBL19720594 | 0.83 | LMNA (0.40) | NR1D1MAPTALDH1A1LMNAUSP30 | |
| SCHEMBL19720568 | 0.82 | NR1D1 (0.39) | NR1D1MAPTALDH1A1LMNAUSP30 | |
| SCHEMBL19720629 | 0.82 | PDE4B (0.42) | NR1D1MAPTALDH1A1LMNAUSP30 | |
| SCHEMBL16895884 | 0.79 | USP30 (0.47) | MAPTALDH1A1LMNAUSP30KMT2A | |
| SCHEMBL29480854 | 0.79 | USP30 (0.47) | MAPTALDH1A1LMNAUSP30KMT2A | |
| SCHEMBL16895885 | 0.79 | USP30 (0.47) | MAPTALDH1A1LMNAUSP30KMT2A | |
| SCHEMBL19720790 | 0.77 | ALDH1A1 (0.42) | NR1D1MAPTALDH1A1LMNAKMT2A | |
| SCHEMBL19720602 | 0.75 | HPGD (0.39) | NR1D1MAPTALDH1A1USP30GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3257848-A1 | COMPOUNDS AND COMPOSITIONS FOR MODULATING EGFR ACTIVITY | Novartis AG (CH) | 2017-12-20 | — | — | EP | disclosed |