Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 8/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.35 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19720598 | 0.84 | MEN1 (0.37) | UCHL1USP30MAPTALDH1A1MEN1 | |
| SCHEMBL19190254 | 0.83 | HPGD (0.41) | HPGDOPRK1UCHL1USP30MAPT | |
| SCHEMBL19720594 | 0.75 | LMNA (0.40) | USP30MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL19720587 | 0.75 | NR1D1 (0.42) | USP30MAPTALDH1A1KMT2AGPR119 | |
| SCHEMBL19720568 | 0.74 | NR1D1 (0.39) | USP30MAPTALDH1A1GPR119NR1D1 | |
| SCHEMBL19720770 | 0.74 | NR1D1 (0.45) | HPGDUSP30MAPTALDH1A1MEN1 | |
| SCHEMBL19720629 | 0.74 | PDE4B (0.42) | HPGDUSP30MAPTALDH1A1GPR119 | |
| SCHEMBL16903327 | 0.74 | USP30 (0.42) | UCHL1USP30MAPTALDH1A1MEN1 | |
| SCHEMBL16901736 | 0.71 | MEN1 (0.41) | USP30MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL19190253 | 0.70 | ALDH1A1 (0.38) | UCHL1USP30MAPTALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3257848-A1 | COMPOUNDS AND COMPOSITIONS FOR MODULATING EGFR ACTIVITY | Novartis AG (CH) | 2017-12-20 | — | — | EP | disclosed |