Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1509089 | 1.00 | L3MBTL1 (0.51) | L3MBTL1ALDH1A1HSD17B10LMNAALOX15 | |
| SCHEMBL8907388 | 0.85 | CNR2 (0.44) | LMNACYP1A2CYP3A4ABCB11TSHR | |
| SCHEMBL7387122 | 0.83 | ALDH1A1 (0.50) | L3MBTL1ALDH1A1HSD17B10LMNAALOX15 | |
| SCHEMBL1969077 | 0.83 | MAPT (0.53) | L3MBTL1ALDH1A1HSD17B10LMNAALOX15 | |
| SCHEMBL1968658 | 0.83 | MAPT (0.53) | L3MBTL1ALDH1A1HSD17B10LMNAALOX15 | |
| SCHEMBL6135621 | 0.82 | NPSR1 (0.50) | L3MBTL1ALDH1A1LMNAMAPK1RECQL | |
| SCHEMBL13070710 | 0.82 | TSHR (0.40) | ALDH1A1LMNACYP1A2CYP3A4ABCB11 | |
| SCHEMBL6135476 | 0.82 | NPSR1 (0.50) | L3MBTL1ALDH1A1LMNAMAPK1RECQL | |
| SCHEMBL204187 | 0.82 | NPSR1 (0.50) | L3MBTL1ALDH1A1LMNAMAPK1RECQL | |
| SCHEMBL2490473 | 0.82 | CYP3A4 (0.58) | ALDH1A1MAPK1TDP1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8168667-B2 | Imidazolidine derivatives, uses therefor, preparation thereof and compositions comprising such | GALAPAGOS NV (BE) | 2012-05-01 | — | — | US | disclosed |
| EP-2026799-B1 | IMIDAZOLIDINE DERIVATIVES, USES THEREFOR, PREPARATION THEREOF AND COMPOSITIONS COMPRISING SUCH | GALAPAGOS SAS (FR) | 2011-06-22 | — | — | EP | disclosed |