Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HHAT | Q5VTY9 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | THPO | P40225 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4751291 | 0.85 | HHAT (0.38) | NPC1RAB9AHHATMAPK1NPSR1 | |
| SCHEMBL14970374 | 0.84 | HHAT (0.43) | NPC1RAB9AHHATMAPK1NPSR1 | |
| SCHEMBL13194702 | 0.83 | NPC1 (0.35) | NPC1RAB9AHHATMAPK1GRIN2B | |
| SCHEMBL15490061 | 0.77 | OPRM1 (0.38) | NPC1RAB9AMAPK1PKM | |
| SCHEMBL11604417 | 0.76 | LHCGR (0.48) | NPC1RAB9AGRIN2B | |
| SCHEMBL11606554 | 0.76 | GAA (0.41) | ALOX15TSHR | |
| SCHEMBL11607640 | 0.74 | LHCGR (0.49) | NPC1RAB9AMAPK1NFKB1 | |
| SCHEMBL3307496 | 0.73 | HHAT (0.45) | HHATMAPK1NPSR1GRIN2B | |
| SCHEMBL4751946 | 0.73 | HHAT (0.45) | HHATMAPK1NPSR1GRIN2B | |
| SCHEMBL3307502 | 0.73 | HHAT (0.45) | HHATMAPK1NPSR1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780337-B1 | SUBSTITUTED CYCLOPROPYL COMPOUNDS USEFUL AS GPR119 AGONISTS | MERCK SHARP & DOHME (US) | 2017-12-20 | — | — | EP | disclosed |