Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.54 |
| ▸ | BRD2 | P25440 | 1/20 | 0.54 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.54 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13020361 | 0.85 | HDAC3 (0.64) | BRD4BRD2BRD3BRDTSMN1; SMN2 | |
| SCHEMBL13332848 | 0.81 | SMN1; SMN2 (0.44) | SMN1; SMN2MAPTKDM4EHDAC3HDAC4 | |
| SCHEMBL4540682 | 0.79 | PDPK1 (0.45) | SMN1; SMN2MAPTHDAC3HDAC4HDAC1 | |
| SCHEMBL4619122 | 0.77 | HDAC3 (0.40) | BRD4SMN1; SMN2KDM4EHDAC3HDAC4 | |
| SCHEMBL29001250 | 0.77 | LMNA (0.58) | BRD4BRD2BRD3BRDTSMN1; SMN2 | |
| SCHEMBL1244152 | 0.77 | ALDH1A1 (0.55) | BRD4BRD2BRD3BRDTSMN1; SMN2 | |
| SCHEMBL15804049 | 0.77 | BRD4 (0.54) | BRD4BRD2BRD3BRDTSMN1; SMN2 | |
| SCHEMBL13020396 | 0.75 | HDAC3 (0.81) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL272388 | 0.75 | EGLN1 (0.75) | BRD4BRD2BRD3BRDTSMN1; SMN2 | |
| SCHEMBL16899407 | 0.75 | MAPK14 (0.53) | BRD4BRD2BRD3BRDTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3436461-B1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | INCYTE CORP (US) | 2023-11-01 | — | — | EP | disclosed |
| EP-2560967-B1 | Heterocyclic carboxylic acid amides as PDK1 inihibitors | BOEHRINGER INGELHEIM INT (DE) | 2017-12-20 | — | — | EP | disclosed |