Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12894237 | 0.78 | PIK3CG (0.54) | GAAALDH1A1DYRK1APIK3CGPIK3CD | |
| SCHEMBL48461 | 0.74 | PIK3CG (0.76) | GAAALDH1A1KDM4EMEN1USP2 | |
| SCHEMBL9570867 | 0.71 | ALDH1A1 (0.47) | GAAALDH1A1DYRK1APIK3CGPIK3CD | |
| SCHEMBL24599388 | 0.69 | ALDH1A1 (0.48) | ALDH1A1LMNATSHRPIK3CGPIK3CD | |
| SCHEMBL2835357 | 0.68 | RXFP1 (0.70) | GAAALDH1A1KDM4EMEN1LMNA | |
| SCHEMBL28504020 | 0.68 | JAK2 (0.77) | ALDH1A1KDM4EMEN1LMNAMAPT | |
| SCHEMBL24624393 | 0.67 | PIK3CD (0.46) | MAPTDYRK1APIK3CGPIK3CDPIK3CA | |
| SCHEMBL155142 | 0.67 | RAB9A (0.57) | ALDH1A1MEN1MAPTKMT2APIK3CG | |
| SCHEMBL2895656 | 0.66 | NR3C1 (0.56) | MEN1MAPTKMT2ARXFP1FFAR2 | |
| SCHEMBL10963101 | 0.66 | ALDH1A1 (0.45) | GAAALDH1A1PIK3CGPIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2986604-B1 | PYRIMIDINE-SUBSTITUTED PYRROLIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | BOEHRINGER INGELHEIM INT (DE) | 2017-12-20 | — | — | EP | disclosed |