Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 11/20 | 0.50 |
| ▸ | MAPT | P10636 | 10/20 | 0.50 |
| ▸ | HPGD | P15428 | 5/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.48 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29589229 | 1.00 | ACHE (0.53) | ACHEL3MBTL1MAPTHPGDPOLB | |
| SCHEMBL5254927 | 0.83 | KDM4E (0.66) | MAPTHPGDPOLBALDH1A1MAPK1 | |
| SCHEMBL21497011 | 0.83 | KDM4E (0.41) | MAPTHPGDALDH1A1MAPK1MEN1 | |
| SCHEMBL7480447 | 0.83 | KDM4E (0.41) | MAPTALDH1A1MAPK1MEN1KMT2A | |
| SCHEMBL30617423 | 0.83 | KDM4E (0.41) | MAPTHPGDALDH1A1MAPK1MEN1 | |
| SCHEMBL10169473 | 0.81 | SMN1; SMN2 (0.43) | ACHEL3MBTL1MAPTPOLBCYP2C9 | |
| SCHEMBL7634998 | 0.81 | ACHE (0.68) | ACHEL3MBTL1MAPTHPGDPOLB | |
| SCHEMBL24036298 | 0.81 | ALDH1A1 (0.46) | ACHEL3MBTL1MAPTHPGDPOLB | |
| SCHEMBL22579791 | 0.81 | ALDH1A1 (0.49) | MAPTPOLBCYP2C19ALDH1A1MEN1 | |
| SCHEMBL18305473 | 0.81 | L3MBTL1 (0.40) | ACHEL3MBTL1MAPTHPGDCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109328187-B | Novel compound with FGFR (FGFR) inhibitory activity as well as preparation and application thereof | 中国科学院上海药物研究所 | 2022-04-26 | — | — | CN | disclosed |
| EP-3486244-A1 | NEW COMPOUND HAVING FGFR INHIBITORY ACTIVITY AND PREPARATION AND APPLICATION THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2019-05-22 | — | — | EP | disclosed |
| EP-3486244-A1 | NEW COMPOUND HAVING FGFR INHIBITORY ACTIVITY AND PREPARATION AND APPLICATION THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2019-05-22 | — | — | EP | disclosed |
| WO-2017215485-A1 | NEW COMPOUND HAVING FGFR INHIBITORY ACTIVITY AND PREPARATION AND APPLICATION THEREOF | 中国科学院上海药物研究所 | 2017-12-21 | — | — | WO | disclosed |