Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9631905 | 0.94 | FFAR1 (0.43) | KDM4ENFE2L2PTGS1MAPK1LMNA | |
| SCHEMBL29679059 | 0.94 | FFAR1 (0.43) | KDM4ENFE2L2PTGS1MAPK1LMNA | |
| SCHEMBL15677622 | 0.85 | KDM4E (0.40) | KDM4EGAAMAPTTSHRNFE2L2 | |
| SCHEMBL29589229 | 0.83 | ACHE (0.53) | KDM4EGAAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL29559341 | 0.83 | FFAR1 (0.42) | KDM4ELMNAHTTKCNH2FFAR1 | |
| SCHEMBL19731472 | 0.83 | ACHE (0.53) | KDM4EGAAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL28665291 | 0.82 | ALDH1A1 (0.34) | KDM4EMAPTALDH1A1MAPK1MEN1 | |
| SCHEMBL1919969 | 0.82 | LMNA (0.54) | KDM4EMAPTTSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL10203021 | 0.81 | KDM4E (0.37) | KDM4EGAAMAPTTSHRNFE2L2 | |
| SCHEMBL12129028 | 0.81 | KDM4E (0.59) | KDM4EGAAMAPTTSHRNFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1068184-B1 | N-ARYLOXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | WYETH CORP (US) | 2002-09-04 | — | — | EP | disclosed |
| EP-1068184-A1 | N-ARYLOXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-01-17 | — | — | EP | disclosed |
| US-6110956-A | ANTIDEPRESSANTS TREATING DISORDERS OF THE SEROTONIN-AFFECTED NEUROLOGICAL SYSTEMS | AMERICAN HOME PRODUCTS CORP. (US) | 2000-08-29 | — | — | US | disclosed |
| WO-1999051576-A1 | N-ARYLOXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-10-14 | — | — | WO | disclosed |