Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 2/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19726599 | 0.83 | KIF11 (0.44) | KIF11LRRK2 | |
| SCHEMBL22702214 | 0.74 | EPHX1 (0.38) | FYNMAPK10LRRK2 | |
| SCHEMBL22797016 | 0.74 | FYN (0.38) | FYNMAPK10LRRK2TRPA1 | |
| SCHEMBL19726603 | 0.73 | KIF11 (0.49) | KIF11 | |
| SCHEMBL22702052 | 0.72 | FYN (0.39) | FYNMAPK10LRRK2 | |
| SCHEMBL19726596 | 0.70 | CA2 (0.38) | KIF11TRPA1 | |
| SCHEMBL8679577 | 0.69 | PDCD1 (0.50) | KIF11TRPA1 | |
| SCHEMBL9261823 | 0.69 | KIF11 (0.47) | KIF11MAPK10TRPA1 | |
| SCHEMBL19726594 | 0.64 | AKT1 (0.43) | LRRK2TRPA1 | |
| SCHEMBL12068479 | 0.64 | MAPT (0.61) | KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10316017-B2 | COT modulators and methods of use thereof | GILEAD SCIENCES, INC. (US) | 2019-06-11 | — | — | US | disclosed |
| US-20170362201-A1 | COT MODULATORS AND METHODS OF USE THEREOF | GILEAD SCIENCES, INC. | 2017-12-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170362201-A1 | COT MODULATORS AND METHODS OF USE THEREOF | BRDT, THRB, HCCS | FYN 2171/4885KIF11 3487/4885MAPK10 3198/4885 |
| US-10316017-B2 | COT modulators and methods of use thereof | BRDT, THRB, HCCS | FYN 2171/4885KIF11 3487/4885MAPK10 3198/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.