Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 11/20 | 0.66 |
| ▸ | HTR1D | P28221 | 9/20 | 0.66 |
| ▸ | HTR1A | P08908 | 7/20 | 0.66 |
| ▸ | HTR2C | P28335 | 6/20 | 0.66 |
| ▸ | HTR1B | P28222 | 6/20 | 0.66 |
| ▸ | HTR7 | P34969 | 4/20 | 0.66 |
| ▸ | HTR6 | P50406 | 4/20 | 0.66 |
| ▸ | HTR2B | P41595 | 3/20 | 0.66 |
| ▸ | HTR4 | Q13639 | 3/20 | 0.66 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.66 |
| ▸ | HTR3B | O95264 | 2/20 | 0.66 |
| ▸ | HTR1E | P28566 | 2/20 | 0.66 |
| ▸ | HTR1F | P30939 | 2/20 | 0.66 |
| ▸ | HTR3A | P46098 | 2/20 | 0.66 |
| ▸ | HTR5A | P47898 | 2/20 | 0.66 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.66 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.66 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31079780 | 1.00 | HTR2A (0.66) | HTR2AHTR1DHTR1AHTR2CHTR1B | |
| SCHEMBL10773237 | 0.89 | HTR2A (0.61) | HTR2AHTR1DHTR1AHTR2CHTR1B | |
| SCHEMBL32669398 | 0.83 | HTR1A (0.66) | HTR2AHTR1DHTR1AHTR2CHTR1B | |
| SCHEMBL25747785 | 0.80 | HTR2C (0.60) | HTR2AHTR1DHTR1AHTR2CHTR1B | |
| SCHEMBL10770864 | 0.80 | HTR1A (0.61) | HTR2AHTR1DHTR1AHTR2CHTR1B | |
| SCHEMBL10772090 | 0.80 | HTR1A (0.61) | HTR2AHTR1DHTR1AHTR2CHTR1B | |
| SCHEMBL27077936 | 0.80 | HTR2A (0.65) | HTR2AHTR1DHTR1AHTR2CHTR1B | |
| SCHEMBL30249043 | 0.80 | HTR1D (1.00) | HTR2AHTR1DHTR1AHTR2CHTR1B | |
| SCHEMBL20970981 | 0.80 | HTR1D (1.00) | HTR2AHTR1DHTR1AHTR2CHTR1B | |
| SCHEMBL32669266 | 0.77 | MPO (0.59) | HTR2AHTR1DHTR1AHTR2CHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2334643-A1 | PHENETHYLAMIDE DERIVATIVES AND THEIR HETEROCYCLIC ANALOGUES | Actelion Pharmaceuticals Ltd. (CH) | 2011-06-22 | — | — | EP | claimed |
| WO-2010044054-A1 | PHENETHYLAMIDE DERIVATIVES AND THEIR HETEROCYCLIC ANALOGUES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-04-22 | — | — | WO | claimed |
| EP-2334643-A1 | PHENETHYLAMIDE DERIVATIVES AND THEIR HETEROCYCLIC ANALOGUES | Actelion Pharmaceuticals Ltd. (CH) | 2011-06-22 | — | — | EP | disclosed |
| WO-2010044054-A1 | PHENETHYLAMIDE DERIVATIVES AND THEIR HETEROCYCLIC ANALOGUES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-04-22 | — | — | WO | disclosed |