Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.34 |
| ▸ | MMP2 | P08253 | 2/20 | 0.34 |
| ▸ | MMP9 | P14780 | 2/20 | 0.34 |
| ▸ | F2 | P00734 | 3/20 | 0.32 |
| ▸ | F10 | P00742 | 3/20 | 0.32 |
| ▸ | FURIN | P09958 | 1/20 | 0.32 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.31 |
| ▸ | FEN1 | P39748 | 1/20 | 0.31 |
| ▸ | TNKS | O95271 | 1/20 | 0.31 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.31 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.31 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.31 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.31 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.31 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.30 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1972442 | 0.83 | AKR1C3 (0.50) | ERCC5FEN1TNKSPARP15PARP14 | |
| SCHEMBL1970213 | 0.81 | MMP3 (0.41) | HDAC8F2F10NPC1 | |
| SCHEMBL756186 | 0.81 | HDAC8 (0.34) | HDAC8F2F10FURINERCC5 | |
| SCHEMBL1973340 | 0.80 | LMNA (0.36) | HDAC8F2F10FURINTNKS | |
| SCHEMBL1973359 | 0.80 | LMNA (0.36) | HDAC8F2F10FURINTNKS | |
| SCHEMBL2809177 | 0.79 | GRIA2 (0.47) | GRIA2 | |
| SCHEMBL1973861 | 0.78 | MAPT (0.44) | F2F10NPC1 | |
| SCHEMBL1969375 | 0.77 | LMNA (0.38) | GRIA2 | |
| SCHEMBL1971789 | 0.76 | MEN1 (0.40) | ADAM17PARP10GRIA2 | |
| SCHEMBL1970202 | 0.74 | ALDH1A1 (0.40) | ADAM17PARP10GRIA2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8236790-B2 | Benzothiadiazepine compounds, a process for their preparation and pharmaceutical compositions containing them | LES LABORATORIES SERVIER (FR) | 2012-08-07 | — | — | US | disclosed |
| EP-2246339-B1 | Derivatives of benzothiazepine and their use as modulators of AMPA and NMDA receptors | SERVIER LAB (FR) | 2011-06-22 | — | — | EP | disclosed |
| EP-2246339-A1 | Derivatives of benzothiazepine and their use as modulators of AMPA and NMDA receptors | Les Laboratoires Servier (FR) | 2010-11-03 | — | — | EP | disclosed |
| US-20100240635-A1 | Benzothiadiazepine compounds, a process for their preparation and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2010-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100240635-A1 | Benzothiadiazepine compounds, a process for their preparation and pharmaceutical compositions containing them | GRIN1, GRIN2B, GRIN3A | HDAC8 734/4885ADAM17 1866/4885MMP2 4371/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.