Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ACACB | O00763 | 10/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28731178 | 0.79 | HTR3E (0.52) | MAPTKMT2AALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL11504237 | 0.79 | KMT2A (0.49) | MAPTKMT2AALDH1A1USP2ALOX15 | |
| SCHEMBL24352426 | 0.76 | L3MBTL1 (0.43) | MAPTKMT2AALDH1A1ALOX15KDM4E | |
| SCHEMBL20000542 | 0.76 | MAPT (0.66) | MAPTKMT2AALDH1A1USP2ALOX15 | |
| SCHEMBL15064578 | 0.73 | ADRB2 (0.41) | MAPTALDH1A1KDM4EACACB | |
| SCHEMBL20217190 | 0.72 | ADRB1 (0.47) | MAPTKMT2AALDH1A1USP2ALOX15 | |
| SCHEMBL2244406 | 0.72 | ACACB (0.43) | MAPTKMT2AALDH1A1USP2ALOX15 | |
| SCHEMBL5269363 | 0.72 | ACACB (0.43) | MAPTKMT2AALDH1A1USP2ALOX15 | |
| SCHEMBL2484638 | 0.71 | ESR2 (0.53) | KMT2AALDH1A1KDM4ESMN1; SMN2GLA | |
| SCHEMBL2484641 | 0.71 | ESR2 (0.53) | KMT2AALDH1A1KDM4ESMN1; SMN2GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017216283-A1 | HETEROCYCLIC COMPOUNDS AS ANTIBACTE RIALS | JANSSEN SCIENCES IRELAND UC (IE) | 2017-12-21 | — | — | WO | disclosed |