Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 3/20 | 0.54 |
| ▸ | MAOA | P21397 | 5/20 | 0.49 |
| ▸ | MAOB | P27338 | 5/20 | 0.49 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.49 |
| ▸ | GRM5 | P41594 | 1/20 | 0.48 |
| ▸ | PRKCI | P41743 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.47 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.42 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19734014 | 0.91 | CYP1A2 (0.56) | HSD17B1CYP2A6GRM5CNR2CYP1A2 | |
| SCHEMBL30641498 | 0.88 | MAOA (0.49) | HSD17B1MAOAMAOBCYP2A6CNR2 | |
| SCHEMBL23351094 | 0.81 | CYP11B1 (0.47) | CYP2A6CNR2CYP1A2CYP11B1CYP11B2 | |
| SCHEMBL4024459 | 0.78 | CYP11B1 (0.51) | CYP2A6CNR2CYP1A2CYP11B1CYP11B2 | |
| SCHEMBL7584101 | 0.78 | HSD17B1 (0.73) | HSD17B1MAOAMAOBCYP2A6GRM5 | |
| SCHEMBL17374742 | 0.77 | HSD17B1 (0.51) | HSD17B1MAOAMAOBCYP2A6GRM5 | |
| SCHEMBL4025451 | 0.76 | CYP11B1 (0.50) | CYP2A6CNR2CYP1A2CYP11B1CYP11B2 | |
| SCHEMBL7507255 | 0.75 | HSD17B1 (0.69) | HSD17B1MAOAMAOBCYP2A6GRM5 | |
| SCHEMBL21222886 | 0.74 | HSD17B1 (0.68) | HSD17B1MAOAMAOBCYP2A6GRM5 | |
| SCHEMBL7505292 | 0.73 | CYP11B1 (0.83) | HSD17B1MAOAMAOBPRKCICYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0721942-B1 | TETRACYCLIC COMPOUND | KYOWA HAKKO KOGYO KK (JP) | 2002-06-05 | — | — | EP | disclosed |
| US-5646283-A | IMMUNOSUPPRESSANTS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-07-08 | — | — | US | disclosed |
| EP-0721942-A1 | NOVEL TETRACYCLIC COMPOUND | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1996-07-17 | — | — | EP | disclosed |