Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KIF11 | P52732 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29009182 | 0.72 | CA12 (0.43) | ALDH1A1LMNATSHRKDM4EGAA | |
| SCHEMBL18025267 | 0.72 | KIF11 (0.75) | DHFRTSHRKIF11CA1CA2 | |
| SCHEMBL19752667 | 0.72 | KIF11 (0.75) | DHFRTSHRKIF11CA1CA2 | |
| SCHEMBL5347891 | 0.72 | KIF11 (0.75) | DHFRTSHRKIF11CA1CA2 | |
| SCHEMBL17863914 | 0.71 | DHFR (0.51) | DHFRALDH1A1LMNATSHRTRPC5 | |
| SCHEMBL17863913 | 0.71 | DHFR (0.51) | DHFRALDH1A1LMNATSHRTRPC5 | |
| SCHEMBL17863910 | 0.71 | DHFR (0.51) | DHFRALDH1A1LMNATSHRTRPC5 | |
| SCHEMBL30576343 | 0.71 | DHFR (0.51) | DHFRALDH1A1LMNATSHRTRPC5 | |
| SCHEMBL27897208 | 0.71 | DHFR (0.57) | DHFRALDH1A1LMNATSHRTRPC5 | |
| SCHEMBL29009201 | 0.70 | ALDH1A1 (0.49) | ALDH1A1KDM4EGAACA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240199609-A1 | COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2 | NOVARTIS AG (CH) | 2024-06-20 | — | — | US | disclosed |
| US-11905283-B2 | Compounds and compositions for inhibiting the activity of SHP2 | NOVARTIS AG (CH) | 2024-02-20 | — | — | US | disclosed |
| CN-114057689-A | Compounds and compositions for inhibiting SHP2 activity | 诺华股份有限公司 | 2022-02-18 | — | — | CN | disclosed |
| CN-109415360-B | Compounds and compositions for inhibiting SHP2 activity | 诺华股份有限公司 | 2021-11-02 | — | — | CN | disclosed |
| US-20210300919-A1 | COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2 | NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, INC. | 2021-09-30 | — | — | US | disclosed |
| US-10934285-B2 | Compounds and compositions for inhibiting the activity of SHP2 | NOVARTIS AG (CH) | 2021-03-02 | — | — | US | disclosed |
| EP-3468972-B1 | COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2 | NOVARTIS AG (CH) | 2020-05-20 | — | — | EP | disclosed |
| WO-2017216706-A1 | COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2 | NOVARTIS AG (CH) | 2017-12-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10934285-B2 | Compounds and compositions for inhibiting the activity of SHP2 | PTPN1, PTPN2, PTPN5 | DHFR 2300/4885ALDH1A1 3978/4885LMNA 4664/4885 |
| US-11905283-B2 | Compounds and compositions for inhibiting the activity of SHP2 | PTPN1, PTPN2, PTPN5 | DHFR 2300/4885ALDH1A1 3978/4885LMNA 4664/4885 |
| US-20240199609-A1 | COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2 | PTPN1, PTPN2, PTPN5 | DHFR 2300/4885ALDH1A1 3978/4885LMNA 4664/4885 |
| US-20210300919-A1 | COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2 | PTPN1, PTPN2, PTPN5 | DHFR 2300/4885ALDH1A1 3978/4885LMNA 4664/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.