Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19736663 | 0.90 | ALDH1A1 (0.38) | ALDH1A1KDM4ELMNAGAAMAPT | |
| SCHEMBL19736660 | 0.82 | MAPT (0.40) | ALDH1A1KDM4ELMNAGAAMAPT | |
| SCHEMBL19736758 | 0.77 | NOS2 (0.34) | ALDH1A1KDM4ELMNAGAAMAPT | |
| SCHEMBL19736756 | 0.77 | KDM4E (0.33) | ALDH1A1KDM4ELMNAGAAMAPT | |
| SCHEMBL19737030 | 0.76 | HTR2A (0.31) | HTR2AHRH1 | |
| SCHEMBL19736886 | 0.75 | KDM4E (0.32) | ALDH1A1KDM4ELMNAGAAMAPT | |
| SCHEMBL15801329 | 0.72 | ALDH1A1 (0.35) | ALDH1A1KDM4ELMNAGAAMAPT | |
| SCHEMBL19736760 | 0.69 | KDM4E (0.33) | ALDH1A1KDM4ELMNAGAAMAPT | |
| SCHEMBL19736885 | 0.68 | KDM4E (0.32) | ALDH1A1KDM4ELMNAGAAMAPT | |
| SCHEMBL19737020 | 0.68 | NOS2 (0.36) | ALDH1A1KDM4ELMNAGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11345653-B2 | Compositions and methods for reactivating cholinesterases | THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE INC. (US) | 2022-05-31 | — | — | US | disclosed |
| US-20190345097-A1 | Compositions and Methods for Reactivating Cholinesterases | The Henry M. Jackson Foundation for the Advancemen t of Military Medicine, Inc. (US) | 2019-11-14 | — | — | US | disclosed |
| WO-2017218886-A1 | COMPOSITIONS AND METHODS FOR REACTIVATING CHOLINESTERASES | THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. (US) | 2017-12-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11345653-B2 | Compositions and methods for reactivating cholinesterases | ACHE, BCHE, CHAT | ALDH1A1 735/4885KDM4E 409/4885LMNA 2251/4885 |
| US-20190345097-A1 | Compositions and Methods for Reactivating Cholinesterases | ACHE, BCHE, CHAT | ALDH1A1 735/4885KDM4E 409/4885LMNA 2251/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.