Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.44 |
| ▸ | CHRM5 known ✓ | P08912 | 2/20 | 0.44 |
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.44 |
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.44 |
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.44 |
| ▸ | CHRM4 known ✓ | P08173 | 1/20 | 0.41 |
| ▸ | CHKA known ✓ | P35790 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL19741468 | 0.94 | KMT2A (0.42) | KMT2ATP53MEN1CYP1A2CYP2D6 | |
| Bromide SCHEMBL8659628 | 0.85 | KMT2A (0.53) | KMT2ATP53MEN1CYP1A2CYP2D6 | |
| Bromide SCHEMBL8659288 | 0.85 | KMT2A (0.64) | KMT2ATP53MEN1CYP1A2CYP2D6 | |
| Bromide SCHEMBL4053581 | 0.85 | KMT2A (0.59) | KMT2ATP53MEN1CYP1A2CYP2D6 | |
| SCHEMBL5301418 | 0.84 | KMT2A (0.63) | KMT2ATP53MEN1CYP1A2CYP2D6 | |
| SCHEMBL5280767 | 0.84 | TP53 (0.57) | KMT2ATP53MEN1CYP1A2CYP2D6 | |
| SCHEMBL5309308 | 0.84 | TP53 (0.52) | KMT2ATP53MEN1CYP1A2CYP2D6 | |
| SCHEMBL5308198 | 0.82 | KMT2A (0.67) | KMT2ATP53MEN1CYP1A2CYP2D6 | |
| SCHEMBL5290239 | 0.82 | TP53 (0.55) | KMT2ATP53MEN1CYP1A2CYP2D6 | |
| SCHEMBL5290688 | 0.82 | KMT2A (0.67) | KMT2ATP53MEN1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10308574-B2 | Reduction catalyst and chemical reactor | KABUSHIKI KAISHA TOSHIBA (JP) | 2019-06-04 | — | — | US | disclosed |
| US-20170369405-A1 | REDUCTION CATALYST AND CHEMICAL REACTOR | KABUSHIKI KAISHA TOSHIBA (JP) | 2017-12-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10308574-B2 | Reduction catalyst and chemical reactor | MPO, NOX4, IDH2 | CHRM2 1110/4885CHRM5 1808/4885CHRM1 877/4885 |
| US-20170369405-A1 | REDUCTION CATALYST AND CHEMICAL REACTOR | MPO, NOX4, IDH2 | CHRM2 1110/4885CHRM5 1808/4885CHRM1 877/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.