Sugi Predict

Sugi Predict / Compounds / SCHEMBL19743542

SCHEMBL19743542

SCHEMBL19743542

COc1cc(F)c(S(=O)(=O)Cl)cc1Cl

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TRPV4 Q9HBA0 1/20 0.50
▸ ALDH1A1 P00352 4/20 0.47
▸ GAA P10253 2/20 0.47
▸ KDM4E B2RXH2 1/20 0.47
▸ TSHR P16473 4/20 0.44
▸ LMNA P02545 2/20 0.42
▸ SMN1; SMN2 Q16637 2/20 0.42
▸ TP53 P04637 2/20 0.42
▸ HSD17B10 Q99714 1/20 0.42
▸ MAPT P10636 2/20 0.42
▸ GLA P06280 1/20 0.41
▸ PTGS2 P35354 2/20 0.41
▸ POLB P06746 1/20 0.41
▸ THRB P10828 2/20 0.40
▸ KMT2A Q03164 2/20 0.40
▸ PTGS1 P23219 1/20 0.40
▸ MEN1 O00255 1/20 0.40
▸ HTT P42858 1/20 0.40
▸ NPC1 O15118 1/20 0.40
▸ HPGD P15428 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29985141 0.93 ALDH1A1 (0.51) TRPV4ALDH1A1GAAKDM4ETSHR
SCHEMBL1939890 0.93 ALDH1A1 (0.51) TRPV4ALDH1A1GAAKDM4ETSHR
SCHEMBL3369690 0.87 TRPV4 (0.50) TRPV4ALDH1A1GAAKDM4ETSHR
SCHEMBL31566943 0.86 TRPV4 (0.54) TRPV4ALDH1A1GAAKDM4ETSHR
SCHEMBL16926596 0.85 TRPV4 (0.49) TRPV4ALDH1A1GAAKDM4ETSHR
SCHEMBL29503407 0.84 PTGS2 (0.49) ALDH1A1GAAKDM4ETSHRLMNA
SCHEMBL10570597 0.83 TRPV4 (0.59) TRPV4ALDH1A1GAAKDM4ETSHR
SCHEMBL27103340 0.83 ALDH1A1 (0.56) TRPV4ALDH1A1GAAKDM4ETSHR
SCHEMBL29984551 0.82 SMN1; SMN2 (0.48) TRPV4ALDH1A1GAATSHRLMNA
SCHEMBL19743262 0.82 SMN1; SMN2 (0.48) TRPV4ALDH1A1GAATSHRLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122055366-A GCN2 and PERK kinase modulators and methods of use thereof 德西费拉制药有限责任公司 2026-05-15 — — CN disclosed
EP-4719606-A2 GCN2 AND PERK KINASE MODULATORS AND METHODS OF USE THEREOF Deciphera Pharmaceuticals, LLC (US) 2026-04-08 — — EP disclosed
WO-2024249493-A2 GCN2 AND PERK KINASE MODULATORS AND METHODS OF USE THEREOF DECIPHERA PHARMACEUTICALS, LLC (US) 2024-12-05 — — WO disclosed
US-11833153-B2 N-(substituted-phenyl)-sulfonamide derivatives as kinase inhibitors NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2023-12-05 — — US disclosed
EP-3472165-B1 N-(SUBSTITUTED-PHENYL)-SULFONAMIDE DERIVATIVES AS KINASE INHIBITORS NERVIANO MEDICAL SCIENCES SRL (IT) 2023-09-06 — — EP disclosed
US-20230107393-A1 N-(SUBSTITUTED-PHENYL)-SULFONAMIDE DERIVATIVES AS KINASE INHIBITORS NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2023-04-06 — — US disclosed
US-11491158-B2 N-(substituted-phenyl)-sulfonamide derivatives as kinase inhibitors NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2022-11-08 — — US disclosed
CN-109311894-B N- (substituted-phenyl) -sulfonamide derivatives as kinase inhibitors 内尔维阿诺医学科学有限公司 2022-03-22 — — CN disclosed
US-20210128563-A1 N-(SUBSTITUTED-PHENYL)-SULFONAMIDE DERIVATIVES AS KINASE INHIBITORS NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2021-05-06 — — US disclosed
US-10918642-B2 N-(substituted-phenyl)-sulfonamide derivatives as kinase inhibitors NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2021-02-16 — — US disclosed
US-20200121686-A1 N-(SUBSTITUTED-PHENYL)-SULFONAMIDE DERIVATIVES AS KINASE INHIBITORS NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2020-04-23 — — US disclosed
US-10561660-B2 N-(substituted-phenyl)-sulfonamide derivatives as kinase inhibitors NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2020-02-18 — — US disclosed
US-20190201406-A1 N-(SUBSTITUTED-PHENYL)-SULFONAMIDE DERIVATIVES AS KINASE INHIBITORS NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2019-07-04 — — US disclosed
EP-3472165-A1 N-(SUBSTITUTED-PHENYL)-SULFONAMIDE DERIVATIVES AS KINASE INHIBITORS Nerviano Medical Sciences S.r.l. (IT) 2019-04-24 — — EP disclosed
WO-2017220477-A1 N-(SUBSTITUTED-PHENYL)-SULFONAMIDE DERIVATIVES AS KINASE INHIBITORS NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2017-12-28 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230107393-A1 N-(SUBSTITUTED-PHENYL)-SULFONAMIDE DERIVATIVES AS KINASE INHIBITORS ATF4, MAP3K1, MAP3K6 TRPV4 3814/4885ALDH1A1 3895/4885GAA 464/4885
US-20190201406-A1 N-(SUBSTITUTED-PHENYL)-SULFONAMIDE DERIVATIVES AS KINASE INHIBITORS ATF4, MAP3K1, MAP3K6 TRPV4 3814/4885ALDH1A1 3895/4885GAA 464/4885
US-11491158-B2 N-(substituted-phenyl)-sulfonamide derivatives as kinase inhibitors ATF4, MAP3K1, MAP3K6 TRPV4 3814/4885ALDH1A1 3895/4885GAA 464/4885
US-11833153-B2 N-(substituted-phenyl)-sulfonamide derivatives as kinase inhibitors ATF4, MAP3K1, MAP3K6 TRPV4 3814/4885ALDH1A1 3895/4885GAA 464/4885
US-20210128563-A1 N-(SUBSTITUTED-PHENYL)-SULFONAMIDE DERIVATIVES AS KINASE INHIBITORS ATF4, MAP3K1, MAP3K6 TRPV4 3814/4885ALDH1A1 3895/4885GAA 464/4885
US-10918642-B2 N-(substituted-phenyl)-sulfonamide derivatives as kinase inhibitors ATF4, MAP3K1, MAP3K6 TRPV4 3814/4885ALDH1A1 3895/4885GAA 464/4885
US-20200121686-A1 N-(SUBSTITUTED-PHENYL)-SULFONAMIDE DERIVATIVES AS KINASE INHIBITORS ATF4, MAP3K1, MAP3K6 TRPV4 3814/4885ALDH1A1 3895/4885GAA 464/4885
US-10561660-B2 N-(substituted-phenyl)-sulfonamide derivatives as kinase inhibitors ATF4, MAP3K1, MAP3K6 TRPV4 3814/4885ALDH1A1 3895/4885GAA 464/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.