SCHEMBL19743790

SCHEMBL19743790

Oc1ccc2c(c1)CN1CN2Cc2cc(O)ccc21

nearest known ligand 0.42

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
ACHE P22303 1/20 0.41
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
GAA P10253 1/20 0.41
PDE3B Q13370 1/20 0.39
PDE3A Q14432 1/20 0.39
ESR1 P03372 1/20 0.39
ESR2 Q92731 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10171019 0.74 BRD4 (0.37)
SCHEMBL30914232 0.74 MAPT (0.42) MEN1KMT2AGAA
SCHEMBL807592 0.73 FYN (0.34) MEN1KMT2AGAA
SCHEMBL31577375 0.73 FYN (0.34) MEN1KMT2AGAA
Ammonia Solution, Strong SCHEMBL18320013 0.72 NOTUM (0.40) GAA
SCHEMBL5516095 0.69 ESR2 (0.50) ESR1ESR2
SCHEMBL5517884 0.68 MEN1 (0.70) MEN1KMT2AGAAESR1ESR2
SCHEMBL20860821 0.67 ALDH1A1 (0.61) MEN1KMT2AGAAESR1ESR2
SCHEMBL18883954 0.67 KMT2A (0.49) MEN1KMT2AGAA
SCHEMBL793253 0.67 ALDH1A1 (0.52) ACHEMEN1KMT2AGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240174821-A1 POLYIMIDE MICROPARTICLES XEROX CORPORATION (US) 2024-05-30 US disclosed
EP-3472170-B1 TROGER'S BASE-BASED MONOMERS, AND POLYMERS, METHODS OF MAKING AND USES THEREOF UNIV KING ABDULLAH SCI & TECH (SA) 2023-10-18 EP disclosed
EP-3472170-B1 TROGER'S BASE-BASED MONOMERS, AND POLYMERS, METHODS OF MAKING AND USES THEREOF UNIV KING ABDULLAH SCI & TECH (SA) 2023-10-18 EP disclosed
US-11014932-B2 Troger's base-based monomers, and polymers, methods of making and uses thereof KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY (SA) 2021-05-25 US disclosed
US-11014932-B2 Troger's base-based monomers, and polymers, methods of making and uses thereof KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY (SA) 2021-05-25 US disclosed
US-20190185481-A1 TROGER'S BASE-BASED MONOMERS, AND POLYMERS, METHODS OF MAKING AND USES THEREOF UNIV KING ABDULLAH SCI & TECH (SA) 2019-06-20 US disclosed
US-20190185481-A1 TROGER'S BASE-BASED MONOMERS, AND POLYMERS, METHODS OF MAKING AND USES THEREOF UNIV KING ABDULLAH SCI & TECH (SA) 2019-06-20 US disclosed
EP-3472170-A1 TROGER'S BASE-BASED MONOMERS, AND POLYMERS, METHODS OF MAKING AND USES THEREOF King Abdullah University Of Science And Technology (SA) 2019-04-24 EP disclosed
WO-2017221135-A1 TROGER'S BASE-BASED MONOMERS, AND POLYMERS, METHODS OF MAKING AND USES THEREOF KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY (SA) 2017-12-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11014932-B2 Troger's base-based monomers, and polymers, methods of making and uses thereof TRDMT1, TRMT1L, TRMT1 ACHE 4178/4885MEN1 222/4885KMT2A 2699/4885
US-20190185481-A1 TROGER'S BASE-BASED MONOMERS, AND POLYMERS, METHODS OF MAKING AND USES THEREOF TRDMT1, TRMT1L, TRMT1 ACHE 4178/4885MEN1 222/4885KMT2A 2699/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.