Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.37 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.35 |
| ▸ | NNMT | P40261 | 2/20 | 0.35 |
| ▸ | LIPE | Q05469 | 3/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | F11 | P03951 | 1/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.32 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27138377 | 0.87 | LIPE (0.35) | UCHL1LIPEFFAR1PDGFRBKDR | |
| SCHEMBL9943204 | 0.83 | LIPE (0.40) | UCHL1LIPELCKDGAT1 | |
| SCHEMBL27136595 | 0.83 | UCHL1 (0.36) | UCHL1LIPEFFAR1USP30GSK3A | |
| SCHEMBL29653311 | 0.83 | LIPE (0.40) | UCHL1LIPELCKDGAT1 | |
| SCHEMBL17863621 | 0.83 | LIPE (0.33) | UCHL1LIPEFFAR1USP30GSK3A | |
| SCHEMBL17841659 | 0.81 | CNR1 (0.42) | KMT2A | |
| SCHEMBL27139969 | 0.81 | GSK3A (0.40) | UCHL1LIPEFFAR1GSK3AGSK3B | |
| SCHEMBL27140662 | 0.81 | USP30 (0.33) | UCHL1LIPEUSP30 | |
| SCHEMBL24667122 | 0.80 | UCHL1 (0.36) | UCHL1LIPEFFAR1USP30GSK3A | |
| SCHEMBL28811820 | 0.79 | NNMT (0.38) | SIRT6UCHL1NNMTLIPEPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3472166-A1 | IMIDAZOPYRIMIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF CANCER | Novartis AG (CH) | 2019-04-24 | — | — | EP | disclosed |
| WO-2017221100-A1 | IMIDAZOPYRIMIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF CANCER | NOVARTIS AG (CH) | 2017-12-28 | — | — | WO | disclosed |