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Sugi Predict / Compounds / SCHEMBL27140662

SCHEMBL27140662

SCHEMBL27140662

Cc1cc(C(=O)C2CC2)ncc1B1OC(C)(C)C(C)(C)O1

nearest known ligand 0.33

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ USP30 Q70CQ3 2/20 0.33
▸ ABL1 P00519 2/20 0.33
▸ LIPE Q05469 3/20 0.32
▸ NPC1 O15118 1/20 0.31
▸ RAB9A P51151 1/20 0.31
▸ SMN1; SMN2 Q16637 1/20 0.31
▸ UCHL1 P09936 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27138377 0.82 LIPE (0.35) USP30LIPEUCHL1
SCHEMBL27136595 0.81 UCHL1 (0.36) USP30LIPEUCHL1
SCHEMBL24665097 0.81 USP30 (0.32) USP30ABL1LIPEUCHL1
SCHEMBL19744093 0.81 SIRT6 (0.37) USP30LIPEUCHL1
SCHEMBL29653311 0.78 LIPE (0.40) LIPEUCHL1
SCHEMBL17863621 0.78 LIPE (0.33) USP30LIPEUCHL1
SCHEMBL9943204 0.78 LIPE (0.40) LIPEUCHL1
SCHEMBL17841659 0.77 CNR1 (0.42) NPC1RAB9ASMN1; SMN2
SCHEMBL27139969 0.76 GSK3A (0.40) LIPERAB9ASMN1; SMN2UCHL1
SCHEMBL24667122 0.75 UCHL1 (0.36) USP30LIPEUCHL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4577546-A1 NAPHTHYRIDINE COMPOUNDS FOR INHIBITION OF RAF KINASES Enliven Inc. (US) 2025-07-02 — — EP disclosed
WO-2024044713-A1 NAPHTHYRIDINE COMPOUNDS FOR INHIBITION OF RAF KINASES ENLIVEN INC. (US) 2024-02-29 — — WO disclosed