Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.36 |
| ▸ | ESPL1 | Q14674 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 4/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MMP14 | P50281 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18708045 | 0.89 | MAPT (0.40) | MAPTALDH1A1TDP1KMT2AHTT | |
| SCHEMBL394821 | 0.83 | VCAM1 (0.41) | MAPTALDH1A1TDP1KMT2AHTT | |
| SCHEMBL394822 | 0.83 | VCAM1 (0.41) | MAPTALDH1A1TDP1KMT2AHTT | |
| SCHEMBL23836925 | 0.79 | VCAM1 (0.38) | MAPTALDH1A1TDP1KMT2AHTT | |
| SCHEMBL6616919 | 0.79 | PTGS2 (0.40) | MAPTALDH1A1TDP1KMT2AHTT | |
| SCHEMBL6616923 | 0.79 | PTGS2 (0.40) | MAPTALDH1A1TDP1KMT2AHTT | |
| SCHEMBL16727135 | 0.75 | MAPT (0.38) | MAPTALDH1A1TDP1KMT2AHTT | |
| SCHEMBL3133057 | 0.74 | VCP (0.38) | MAPTALDH1A1TDP1KMT2AHTT | |
| SCHEMBL13365238 | 0.74 | ALDH1A1 (0.37) | MAPTALDH1A1TDP1KMT2AHTT | |
| SCHEMBL30204572 | 0.74 | VCP (0.38) | MAPTALDH1A1TDP1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3091011-B1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMA (US) | 2017-12-27 | — | — | EP | disclosed |