SCHEMBL197540

SCHEMBL197540

COC(=O)c1ccc(CBr)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.53
CES2 O00748 1/20 0.51
CES1 P23141 1/20 0.51
LOXL2 Q9Y4K0 1/20 0.50
CA1 P00915 1/20 0.50
CA2 P00918 1/20 0.50
RAB9A P51151 5/20 0.49
MAPT P10636 3/20 0.49
NPC1 O15118 3/20 0.48
CASP3 P42574 1/20 0.47
SENP8 Q96LD8 1/20 0.47
SENP7 Q9BQF6 1/20 0.47
SENP6 Q9GZR1 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
CYP4A11 Q02928 2/20 0.46
MGLL Q99685 1/20 0.46
SMN1; SMN2 Q16637 3/20 0.46
ALDH1A1 P00352 1/20 0.46
HPGD P15428 1/20 0.46
AGTR1 P30556 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10484531 0.85 TSHR (0.67) TSHRCA1CA2RAB9AMAPT
SCHEMBL9340188 0.85 TSHR (0.67) TSHRCA1CA2RAB9AMAPT
SCHEMBL33494 0.85 LOXL2 (0.66) TSHRCES2CES1LOXL2CA1
SCHEMBL1509563 0.85 TSHR (0.53) TSHRLOXL2CA1CA2RAB9A
Toluene SCHEMBL27262094 0.84 TDP1 (0.59) TSHRCES2CES1LOXL2CA1
SCHEMBL9875461 0.84 LOXL2 (0.56) TSHRLOXL2RAB9AMAPTCYP4A11
SCHEMBL4050879 0.84 LOXL2 (0.63) TSHRCES2CES1LOXL2CA1
Bromide SCHEMBL4809006 0.84 LOXL2 (0.63) TSHRCES2CES1LOXL2CA1
Methyl Benzoate SCHEMBL28154074 0.84 TSHR (0.76) TSHRCA1CA2RAB9AMAPT
SCHEMBL27262281 0.82 MGLL (0.56) TSHRCES2CES1LOXL2CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4289838-A2 ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME Celgene Corporation (US) 2023-12-13 EP disclosed
EP-3599236-B1 ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME CELGENE CORP (US) 2023-08-23 EP disclosed
US-20220411402-A1 ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME CELGENE CORPORATION 2022-12-29 US disclosed
US-11414399-B2 Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same CELGENE CORPORATION (US) 2022-08-16 US disclosed
US-20200231567-A1 ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME CELGENE CORPORATION 2020-07-23 US disclosed
US-10669257-B2 Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same CELGENE CORPORATION (US) 2020-06-02 US disclosed
EP-3599236-A1 ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME Celgene Corporation (US) 2020-01-29 EP disclosed
EP-3202460-B1 ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME CELGENE CORP (US) 2019-06-12 EP disclosed
US-20190135780-A1 ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME CELGENE CORPORATION 2019-05-09 US disclosed
EP-3106460-B1 ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME CELGENE CORP (US) 2019-04-10 EP disclosed
EP-0819107-A1 9-SUBSTITUTED PORPHYCENES CYTOPHARM, INC. (US) 1998-01-21 EP disclosed
US-5661178-A Method for effecting vasodilation with (1,5-inter)aryl prostaglandin derivatives ALLERGAN (US) 1997-08-26 US disclosed
US-5637608-A PHOTODYNAMIC THERAPY CYTOPHARM, INC. (US) 1997-06-10 US disclosed
WO-1997018207-A2 NOVEL MACROCYCLIC COMPOUNDS AS METALLOPROTEASE INHIBITORS THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1997-05-22 WO disclosed
WO-1997009049-A2 METHOD FOR EFFECTING VASODILATION WITH (1,5-INTER)ARYL PROSTAGLANDIN DERIVATIVES ALLERGAN (US) 1997-03-13 WO disclosed
US-5610175-A 9-Substituted porphycenes CYTOPHARM, INC. (US) 1997-03-11 US disclosed
WO-1996031451-A1 9-SUBSTITUTED PORPHYCENES CYTOPHARM, INC. (US) 1996-10-10 WO disclosed
WO-1996031452-A1 9-SUBSTITUTED PORPHYCENES CYTOPHARM, INC. (US) 1996-10-10 WO disclosed
EP-0733033-A1 PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS ZENECA LIMITED (GB) 1996-09-25 EP disclosed
WO-1996011902-A1 PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS ZENECA LIMITED (GB) 1996-04-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10669257-B2 Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same CYP3A7, CYP3A4, CYP3A43 TSHR 2970/4885CES2 178/4885CES1 432/4885
US-20220411402-A1 ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME CYP3A7, CYP3A4, CYP3A43 TSHR 2970/4885CES2 178/4885CES1 432/4885
US-20200231567-A1 ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME CYP3A7, CYP3A4, CYP3A43 TSHR 2970/4885CES2 178/4885CES1 432/4885
US-11414399-B2 Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same CYP3A7, CYP3A4, CYP3A43 TSHR 2970/4885CES2 178/4885CES1 432/4885
US-20190135780-A1 ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME CYP3A7, CYP3A4, CYP3A43 TSHR 2970/4885CES2 178/4885CES1 432/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.