Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.39 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.38 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | VNN1 | O95497 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19766587 | 0.87 | PLA2G1B (0.43) | TDP1SMN1; SMN2L3MBTL1PLA2G1BATG4B | |
| SCHEMBL23219795 | 0.82 | VNN1 (0.41) | TDP1SMN1; SMN2L3MBTL1PLA2G1BATG4B | |
| SCHEMBL20940096 | 0.80 | PDE10A (0.39) | TDP1ALDH1A1SMN1; SMN2L3MBTL1PLA2G1B | |
| SCHEMBL20940095 | 0.77 | PDE10A (0.37) | TDP1SMN1; SMN2L3MBTL1PLA2G1BATG4B | |
| SCHEMBL13466364 | 0.75 | PLA2G1B (0.45) | TDP1ALDH1A1SMN1; SMN2L3MBTL1PLA2G1B | |
| SCHEMBL13467096 | 0.73 | PDE10A (0.56) | TDP1SMN1; SMN2L3MBTL1NAMPTVNN1 | |
| SCHEMBL3232177 | 0.70 | IRAK4 (0.42) | TDP1SMN1; SMN2HIF1AL3MBTL1VNN1 | |
| SCHEMBL20254512 | 0.70 | SMN1; SMN2 (0.41) | TDP1SMN1; SMN2L3MBTL1VNN1PDE10A | |
| SCHEMBL23880060 | 0.70 | SCN9A (0.46) | ALDH1A1ALOX15SMN1; SMN2L3MBTL1PLA2G1B | |
| SCHEMBL21379463 | 0.68 | PDE7A (0.48) | SMN1; SMN2L3MBTL1PLA2G1BATG4BNAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10975088-B2 | Imidazo[2,1-f][1,2,4]triazine compounds as pi3k-y inhibitors | INCYTE CORPORATION (US) | 2021-04-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10975088-B2 | Imidazo[2,1-f][1,2,4]triazine compounds as pi3k-y inhibitors | PIK3R5, PIK3CD, PIK3CA | TDP1 383/4885ALDH1A1 2818/4885TP53 1202/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.